| 2022-03-26 15:00:0026.03.2022 | LUCAF Owls | 0 - 32 | Lugano Rebels | NLC | |
| 2022-03-27 14:00:0027.03.2022 | Morges Bandits | 28 - 20 | Orks | NLC | |
| 2022-03-27 14:00:0027.03.2022 | Neuchatel Knights | 3 - 14 | Zurich State Spartans | NLC | |
| 2022-03-27 14:00:0027.03.2022 | Niederbipp Ducks | 6 - 53 | Dragons | NLC | |
| 2022-03-27 14:00:0027.03.2022 | Schaffhausen Sharks | 3 - 0 | Langenthal Invaders | NLC | |
| 2022-04-03 14:00:0003.04.2022 | Zurich State Spartans | 10 - 8 | Langenthal Invaders | NLC | |
| 2022-04-10 14:00:0010.04.2022 | Dragons | 50 - 0 | Zofingen Cheetahs | NLC | |
| 2022-04-10 14:00:0010.04.2022 | Niederbipp Ducks | 0 - 24 | Neuchatel Knights | NLC | |
| 2022-04-16 18:00:0016.04.2022 | Langenthal Invaders | 46 - 7 | Neuchatel Knights | NLC | |
| 2022-04-16 18:00:0016.04.2022 | LUCAF Owls | 7 - 0 | Orks | NLC | |
| 2022-04-16 18:00:0016.04.2022 | Zofingen Cheetahs | 0 - 56 | Schaffhausen Sharks | NLC | |
| 2022-04-17 14:00:0017.04.2022 | Morges Bandits | 47 - 6 | Niederbipp Ducks | NLC | |
| 2022-04-23 14:30:0023.04.2022 | Zurich State Spartans | 14:30:00Abgesagt | Zofingen Cheetahs | NLC | |
| 2022-04-23 18:00:0023.04.2022 | Langenthal Invaders | 67 - 6 | Niederbipp Ducks | NLC | |
| 2022-04-23 18:00:0023.04.2022 | Neuchatel Knights | 12 - 5 | LUCAF Owls | NLC | |
| 2022-04-24 14:00:0024.04.2022 | Dragons | 26 - 06 | Orks | NLC | |
| 2022-04-24 14:00:0024.04.2022 | Lugano Rebels | 21 - 40 | Schaffhausen Sharks | NLC | |
| 2022-04-30 14:30:0030.04.2022 | Zurich State Spartans | 7 - 13 | Dragons | NLC | |
| 2022-05-01 14:00:0001.05.2022 | Orks | 0 - 35 | Schaffhausen Sharks | NLC | |
| 2022-05-01 14:00:0001.05.2022 | Morges Bandits | 21 - 35 | Langenthal Invaders | NLC | |
| 2022-05-01 14:00:0001.05.2022 | Zofingen Cheetahs | 0 - 61 | Lugano Rebels | NLC | |
| 2022-05-08 14:00:0008.05.2022 | Dragons | 22 - 12 | Lugano Rebels | NLC | |
| 2022-05-08 14:00:0008.05.2022 | Schaffhausen Sharks | 9 - 0 | Neuchatel Knights | NLC | |
| 2022-05-08 14:00:0008.05.2022 | Zofingen Cheetahs | 6 - 28 | Niederbipp Ducks | NLC | |
| 2022-05-14 18:00:0014.05.2022 | Orks | 7 - 24 | Lugano Rebels | NLC | |
| 2022-05-14 18:00:0014.05.2022 | Niederbipp Ducks | 14 - 15 | LUCAF Owls | NLC | |
| 2022-05-15 14:00:0015.05.2022 | Neuchatel Knights | 40 - 23 | Morges Bandits | NLC | |
| 2022-05-15 14:00:0015.05.2022 | Schaffhausen Sharks | 17 - 03 | Zurich State Spartans | NLC | |
| 2022-05-15 14:00:0015.05.2022 | Zofingen Cheetahs | 0 - 50 | Langenthal Invaders | NLC | |
| 2022-05-21 15:00:0021.05.2022 | LUCAF Owls | 0 - 32 | Schaffhausen Sharks | NLC | |
| 2022-05-22 14:00:0022.05.2022 | Lugano Rebels | 22 - 25 | Morges Bandits | NLC | |
| 2022-05-22 14:00:0022.05.2022 | Neuchatel Knights | 15 - 22 | Dragons | NLC | |
| 2022-05-22 14:00:0022.05.2022 | Niederbipp Ducks | 21 - 35 | Zurich State Spartans | NLC | |
| 2022-05-28 18:00:0028.05.2022 | Langenthal Invaders | 55 - 7 | Orks | NLC | |
| 2022-05-29 14:00:0029.05.2022 | Lugano Rebels | 62 - 0 | Niederbipp Ducks | NLC | |
| 2022-05-29 14:00:0029.05.2022 | Morges Bandits | 53 - 6 | Zofingen Cheetahs | NLC | |
| 2022-05-29 14:30:0029.05.2022 | Zurich State Spartans | 6 - 13 | LUCAF Owls | NLC | |
| 2022-06-05 14:00:0005.06.2022 | LUCAF Owls | 14:00:00Abgesagt | Zofingen Cheetahs | NLC | |
| 2022-06-05 14:00:0005.06.2022 | Lugano Rebels | 48 - 23 | Zurich State Spartans | NLC | |
| 2022-06-05 14:00:0005.06.2022 | Morges Bandits | 0 - 13 | Dragons | NLC | |
| 2022-06-05 14:00:0005.06.2022 | Neuchatel Knights | 16 - 19 | Orks | NLC | |
| 2022-06-11 18:00:0011.06.2022 | Dragons | 20 - 24 | Langenthal Invaders | NLC | |
| 2022-06-11 18:00:0011.06.2022 | Orks | 19 - 12 | Zurich State Spartans | NLC | |
| 2022-06-11 18:00:0011.06.2022 | Niederbipp Ducks | 3 - 35 | Schaffhausen Sharks | NLC | |
| 2022-06-12 14:00:0012.06.2022 | LUCAF Owls | 0 - 50 | Morges Bandits | NLC | |
| 2022-06-18 14:00:0018.06.2022 | Orks | 50 - 0 | Zofingen Cheetahs | NLC | |
| 2022-06-18 18:00:0018.06.2022 | Langenthal Invaders | 28 - 19 | LUCAF Owls | NLC | |
| 2022-06-19 14:00:0019.06.2022 | Lugano Rebels | 21 - 7 | Neuchatel Knights | NLC | |
| 2022-06-19 14:00:0019.06.2022 | Schaffhausen Sharks | 20 - 14 | Dragons | NLC | |
| 2022-06-25 18:00:0025.06.2022 | Orks | 48 - 0 | Niederbipp Ducks | NLC | |
| 2022-06-26 14:00:0026.06.2022 | Dragons | 25 - 19 | LUCAF Owls | NLC | |
| 2022-06-26 14:00:0026.06.2022 | Langenthal Invaders | 48 - 6 | Lugano Rebels | NLC | |
| 2022-06-26 14:30:0026.06.2022 | Zurich State Spartans | 20 - 0 | Morges Bandits | NLC | |
| 2022-07-03 14:00:0003.07.2022 | Schaffhausen Sharks | 42 - 7 | Morges Bandits | NLC | |
| 2022-07-03 14:00:0003.07.2022 | Zofingen Cheetahs | 0 - 42 | Neuchatel Knights | NLC | |
