| Datum | Home | Away | Resultat | Liga |
|---|---|---|---|---|
| 25.09.2022 |  New England Patriots |  Baltimore Ravens | 26 - 37 | NFL |
| 25.09.2022 |  Minnesota Vikings |  Detroit Lions | 28 - 24 | NFL |
| 25.09.2022 |  Miami Dolphins |  Buffalo Bills | 21 - 19 | NFL |
| 25.09.2022 |  Indianapolis Colts |  Kansas City Chiefs | 20 - 17 | NFL |
| 25.09.2022 |  Chicago Bears |  Houston Texans | 23 - 20 | NFL |
| 25.09.2022 |  Carolina Panthers |  New Orleans Saints | 22 - 14 | NFL |
| 25.09.2022 |  Zurich Renegades |  Bern Grizzlies | 26 - 0 | U16 |
| 25.09.2022 |  Thun Tigers |  Winterthur Warriors | 6 - 28 | U16 |
| 25.09.2022 |  Hamburg Sea Devils |  Vienna Vikings | 15 - 27 | ELF |
| 24.09.2022 |  Calanda Broncos |  Basel Gladiators | 44 - 14 | U16 |
| 23.09.2022 |  Cleveland Browns |  Pittsburgh Steelers | 29 - 17 | NFL |
| 20.09.2022 |  Philadelphia Eagles | Minnesota Vikings | 24 - 7 | NFL |
| 20.09.2022 | Buffalo Bills |  Tennessee Titans | 41 - 7 | NFL |
| 19.09.2022 |  Green Bay Packers | Chicago Bears | 27 - 10 | NFL |
| 18.09.2022 |  Las Vegas Raiders |  Arizona Cardinals | 23 - 29 | NFL |
| 18.09.2022 |  Denver Broncos | Houston Texans | 16 - 9 | NFL |
| 18.09.2022 |  Dallas Cowboys |  Cincinnati Bengals | 20 - 17 | NFL |
| 18.09.2022 |  San Francisco 49ers |  Seattle Seahawks | 27 - 7 | NFL |
| 18.09.2022 |  Los Angeles Rams |  Atlanta Falcons | 31 - 27 | NFL |
| 18.09.2022 | Pittsburgh Steelers | New England Patriots | 14 - 17 | NFL |
| 18.09.2022 |  New York Giants | Carolina Panthers | 19 - 16 | NFL |
| 18.09.2022 | New Orleans Saints |  Tampa Bay Buccaneers | 10 - 20 | NFL |
| 18.09.2022 |  Jacksonville Jaguars | Indianapolis Colts | 24 - 0 | NFL |
| 18.09.2022 | Detroit Lions |  Washington Commanders | 36 - 27 | NFL |
| 18.09.2022 | Cleveland Browns |  New York Jets | 30 - 31 | NFL |
| 18.09.2022 | Baltimore Ravens | Miami Dolphins | 38 - 42 | NFL |
| 17.09.2022 |  St. Gallen Wolfpack |  Winterthur Warriors Cardinal | 21 - 20 | NFFL B |
| 17.09.2022 |  Rafz Bulldogs B |  Thun Tigers Flag | 19 - 7 | NFFL B |
| 17.09.2022 |  Basel Spartans Yellow | Basel Spartans Navy | 24 - 62 | NFFL B |
| 17.09.2022 |  ASVZ Mockingbirds |  Luzern Pikes | 14 - 25 | NFFL A |
| 17.09.2022 | Calanda Broncos W |  ASVZ Firebirds W | 18 - 20 | NFFL Women |
| 17.09.2022 |  Aemme Buzzards |  Rafz Bulldogs A | 19 - 46 | NFFL B |
| 17.09.2022 |  Zorros Zürich |  Argovia Pirates Flag | 40 - 6 | NFFL B |
| 17.09.2022 |  Geneva Seahawks W | Winterthur Warriors Ladies | 6 - 40 | NFFL Women |
| 17.09.2022 | Thun Tigers Flag | Winterthur Warriors Cardinal | 31 - 36 | NFFL B |
| 17.09.2022 | Rafz Bulldogs B |  Schottikon Raptors | 45 - 6 | NFFL B |
| 17.09.2022 | Basel Spartans Yellow |  Soly Rhinos | 34 - 44 | NFFL B |
| 17.09.2022 | Luzern Pikes |  ASVZ Blackbirds | 12 - 42 | NFFL A |
| 17.09.2022 | Calanda Broncos W |  Neuchâtel Knights W | 27 - 0 | NFFL Women |
| 17.09.2022 | St. Gallen Wolfpack |  Thurgauer Generals | 18 - 14 | NFFL B |
| 17.09.2022 |  Basel Barbarians | Basel Spartans Navy | 12 - 58 | NFFL B |
| 17.09.2022 | Winterthur Warriors Black |  Geneva Seahawks Flag | 20 - 26 | NFFL B |
| 17.09.2022 | ASVZ Mockingbirds | Winterthur Warriors Gold | 28 - 12 | NFFL A |
| 17.09.2022 | Geneva Seahawks W | ASVZ Firebirds W | 6 - 22 | NFFL Women |
| 17.09.2022 | Zorros Zürich | Rafz Bulldogs A | 39 - 46 | NFFL B |
| 17.09.2022 | Argovia Pirates Flag |  Blackbucks Uni Bern | 8 - 56 | NFFL B |
| 17.09.2022 |  Midland Bouncers Flag | Zurich Renegades Flag | 34 - 27 | NFFL A |
| 17.09.2022 | Aemme Buzzards | Basel Barbarians | 20 - 25 | NFFL B |
| 17.09.2022 | Schottikon Raptors | Winterthur Warriors Black | 26 - 46 | NFFL B |
| 17.09.2022 | Geneva Seahawks Flag | Soly Rhinos | 14 - 38 | NFFL B |
