| Datum | Home | Away | Resultat | Liga |
|---|---|---|---|---|
| 21.05.2022 |  Rafz Bulldogs A |  Rafz Bulldogs B | 46 - 12 | NFFL B |
| 21.05.2022 |  Basel Barbarians |  Soly Rhinos | 12 - 64 | NFFL B |
| 21.05.2022 |  Calanda Broncos U13 |  Winterthur Warriors U13 | 26 - 13 | Flag U13 |
| 21.05.2022 |  Zurich Renegades B U16 |  Gladiators Basel U16 | 37 - 50 | Flag U16 |
| 21.05.2022 |  Basel Spartans Yellow |  Blackbucks Uni Bern | 20 - 48 | NFFL B |
| 21.05.2022 |  Argovia Pirates Flag | Basel Spartans Navy | 0 - 56 | NFFL B |
| 21.05.2022 |  Lake Zurich Red Scorpions U13 | Zurich Renegades B U13 | 6 - 48 | Flag U13 |
| 21.05.2022 | Argovia Pirates U13 | Zurich Renegades A U13 | 0 - 83 | Flag U13 |
| 21.05.2022 | Argovia Pirates U16 | Zurich Renegades A U16 | 48 - 38 | Flag U16 |
| 21.05.2022 |  St. Gallen Wolfpack |  Aemme Buzzards | 45 - 25 | NFFL B |
| 21.05.2022 |  Geneva Seahawks Flag |  Schottikon Raptors | 57 - 0 | NFFL B |
| 21.05.2022 |  Thun Tigers Flag |  Zorros Zürich | 7 - 53 | NFFL B |
| 21.05.2022 | Gladiators Basel U16 |  Luzern Lions U16 | 48 - 26 | Flag U16 |
| 21.05.2022 | Basel Spartans U16 | Winterthur Warriors U16 | 30 - 35 | Flag U16 |
| 21.05.2022 |  Thurgauer Generals | Winterthur Warriors Black | 7 - 20 | NFFL B |
| 21.05.2022 | Rafz Bulldogs B | Winterthur Warriors Cardinal | 26 - 48 | NFFL B |
| 21.05.2022 | Rafz Bulldogs A | Soly Rhinos | 7 - 42 | NFFL B |
| 15.05.2022 | Zurich Renegades | Basel Gladiators | 0 - 40 | NLA |
| 15.05.2022 |  Zofingen Cheetahs |  Langenthal Invaders | 0 - 50 | NLC |
| 15.05.2022 |  Schaffhausen Sharks |  Zurich State Spartans | 17 - 03 | NLC |
| 15.05.2022 |  Neuchatel Knights |  Morges Bandits | 40 - 23 | NLC |
| 15.05.2022 | Luzern Lions |  Fribourg Cardinals | 21 - 0 | NLB |
| 15.05.2022 |  Geneva Whoppers |  Bienna Jets | 18 - 25 | NLB |
| 15.05.2022 | Neuchatel Knights | Morges Bandits | ? - ? | U19 Challenge League |
| 15.05.2022 | Zurich Renegades |  Thun Tigers | 24 - 33 | U19 Elite |
| 14.05.2022 | Calanda Broncos | Budapest Wolves | 35 - 28 | CEFL |
| 14.05.2022 |  Thonon Black Panthers | Flash de La Courneuve | 27 - 45 | CEFL |
| 14.05.2022 |  Niederbipp Ducks |  LUCAF Owls | 14 - 15 | NLC |
| 14.05.2022 |  Glarus Orks |  Lugano Rebels | 7 - 24 | NLC |
| 14.05.2022 | Argovia Pirates |  St. Gallen Bears | 15 - 27 | NLB |
| 14.05.2022 | Luzern Lions U16 | Gladiators Basel U16 | 8 - 20 | Flag U16 |
| 14.05.2022 | Zurich Renegades Flag |  Luzern Pikes | 19 - 40 | NFFL A |
| 14.05.2022 |  ASVZ Mockingbirds |  Midland Bouncers Flag | 13 - 6 | NFFL A |
| 14.05.2022 | Parma Panthers |  Danube Dragons | 21 - 10 | CEFL |
| 14.05.2022 | Zurich Renegades B U16 | Zurich Renegades A U16 | 7 - 45 | Flag U16 |
| 14.05.2022 | Winterthur Warriors U16 | Luzern Lions U16 | 7 - 63 | Flag U16 |
| 14.05.2022 | Argovia Pirates |  Bern Grizzlies | 15 - 0 | U19 Elite |
| 14.05.2022 | Gladiators Basel U16 | Argovia Pirates U16 | 25 - 26 | Flag U16 |
| 14.05.2022 | Luzern Pikes | ASVZ Mockingbirds | 18 - 25 | NFFL A |
| 14.05.2022 | Zurich Renegades B U16 | Basel Spartans U16 | 58 - 7 | Flag U16 |
| 14.05.2022 | Winterthur Warriors Gold | Zurich Renegades Flag | 48 - 27 | NFFL A |
| 14.05.2022 | Winterthur Warriors U16 | Zurich Renegades A U16 | 0 - 55 | Flag U16 |
| 14.05.2022 | Basel Spartans U16 | Argovia Pirates U16 | 0 - 52 | Flag U16 |
| 14.05.2022 | Midland Bouncers Flag | Winterthur Warriors Gold | 19 - 25 | NFFL A |
| 08.05.2022 |  Geneva Seahawks |  Winterthur Warriors | 21 - 7 | NLA |
| 08.05.2022 | Zurich Renegades | Thun Tigers | 19 - 62 | NLA |
| 08.05.2022 | Zofingen Cheetahs | Niederbipp Ducks | 6 - 28 | NLC |
| 08.05.2022 | Schaffhausen Sharks | Neuchatel Knights | 9 - 0 | NLC |
| 08.05.2022 |  Emmen Dragons | Lugano Rebels | 22 - 12 | NLC |
| 08.05.2022 | Luzern Lions | Argovia Pirates | 9 - 14 | NLB |
