| Datum | Home | Away | Resultat | Liga |
|---|---|---|---|---|
| 08.05.2022 |  Fribourg Cardinals |  Bienna Jets | 8 - 23 | NLB |
| 08.05.2022 |  Geneva Seahawks |  Winterthur Warriors | 50 - 0 | U19 Elite |
| 08.05.2022 |  Luzern Lions |  Lugano Rebels | 22 - 0 | U19 Challenge League |
| 08.05.2022 |  Zurich Renegades |  Basel Gladiators | 20 - 27 | U19 Elite |
| 07.05.2022 |  Calanda Broncos | Basel Gladiators | 35 - 6 | NLA |
| 07.05.2022 |  St. Gallen Bears |  Geneva Whoppers | 34 - 0 | NLB |
| 07.05.2022 | St. Gallen Bears |  Thun Tigers | 6 - 58 | U19 Elite |
| 07.05.2022 | Calanda Broncos |  Bern Grizzlies | 36 - 0 | U19 Elite |
| 07.05.2022 |  Neuchatel Knights | Bienna Jets | 0 - 41 | U19 Challenge League |
| 07.05.2022 |  Schwäbisch Hall Unicorns | Örebro Black Knights | 58 - 7 | CEFL |
| 01.05.2022 | Thun Tigers | Geneva Seahawks | 41 - 6 | NLA |
| 01.05.2022 | Bern Grizzlies | Calanda Broncos | 27 - 20 | NLA |
| 01.05.2022 |  Zofingen Cheetahs | Lugano Rebels | 0 - 61 | NLC |
| 01.05.2022 |  Morges Bandits |  Langenthal Invaders | 21 - 35 | NLC |
| 01.05.2022 |  Glarus Orks |  Schaffhausen Sharks | 0 - 35 | NLC |
| 01.05.2022 | Morges Bandits | Luzern Lions | 0 - 56 | U19 Challenge League |
| 01.05.2022 | Thun Tigers | Calanda Broncos | 39 - 43 | U19 Elite |
| 01.05.2022 | Bern Grizzlies | St. Gallen Bears | 33 - 12 | U19 Elite |
| 30.04.2022 |  Argovia Pirates | Fribourg Cardinals | 7 - 3 | NLB |
| 30.04.2022 | Winterthur Warriors | Zurich Renegades | 22 - 14 | NLA |
| 30.04.2022 |  Zurich State Spartans |  Emmen Dragons | 7 - 13 | NLC |
| 30.04.2022 | Winterthur Warriors | Basel Gladiators | 12 - 39 | U19 Elite |
| 30.04.2022 | Argovia Pirates | Geneva Seahawks | 14 - 36 | U19 Elite |
| 30.04.2022 | Bienna Jets | Lugano Rebels | - | U19 Challenge League |
| 24.04.2022 | St. Gallen Bears | Bienna Jets | 28 - 7 | NLB |
| 24.04.2022 | Geneva Seahawks | Calanda Broncos | 0 - 21 | NLA |
| 24.04.2022 | Bern Grizzlies | Thun Tigers | 24 - 7 | NLA |
| 24.04.2022 | Lugano Rebels | Schaffhausen Sharks | 21 - 40 | NLC |
| 24.04.2022 | Emmen Dragons | Glarus Orks | 26 - 06 | NLC |
| 24.04.2022 | Geneva Whoppers | Luzern Lions | 07 - 42 | NLB |
| 24.04.2022 | Lugano Rebels | Neuchatel Knights | 21 - 07 | U19 Challenge League |
| 24.04.2022 | St. Gallen Bears | Calanda Broncos | 0 - 53 | U19 Elite |
| 24.04.2022 | Geneva Seahawks | Zurich Renegades | 36 - 22 | U19 Elite |
| 24.04.2022 | Bern Grizzlies | Winterthur Warriors | 18 - 20 | U19 Elite |
| 23.04.2022 | Neuchatel Knights |  LUCAF Owls | 12 - 5 | NLC |
| 23.04.2022 | Langenthal Invaders |  Niederbipp Ducks | 67 - 6 | NLC |
| 23.04.2022 | Zurich Renegades B U16 | Luzern Lions U16 | 0 - 50 | Flag U16 |
| 23.04.2022 | Gladiators Basel U16 | Zurich Renegades A U16 | 52 - 6 | Flag U16 |
| 23.04.2022 |  Winterthur Warriors U16 |  Basel Spartans U16 | 0 - 78 | Flag U16 |
| 23.04.2022 | Basel Spartans Navy |  Blackbucks Uni Bern | 34 - 57 | NFFL B |
| 23.04.2022 | Calanda Broncos U13 |  Thun Tigers U13 | 19 - 12 | Flag U13 |
| 23.04.2022 | Winterthur Warriors U13 | Zurich Renegades A U13 | 0 - 66 | Flag U13 |
| 23.04.2022 |  Soly Rhinos | Winterthur Warriors Cardinal | 58 - 20 | NFFL B |
| 23.04.2022 | Winterthur Warriors Black |  Zorros Zürich | 32 - 24 | NFFL B |
| 23.04.2022 |  Schottikon Raptors | Thun Tigers Flag | 37 - 32 | NFFL B |
| 23.04.2022 | Zurich Renegades B U13 | Argovia Pirates U13 | 25 - 0 | Flag U13 |
| 23.04.2022 | Gladiators Basel U16 | Winterthur Warriors U16 | 84 - 0 | Flag U16 |
| 23.04.2022 | Argovia Pirates U16 | Zurich Renegades B U16 | 43 - 25 | Flag U16 |
| 23.04.2022 | Calanda Broncos W | Winterthur Warriors Ladies | 28 - 14 | NFFL Women |
| 23.04.2022 | Geneva Seahawks W | Neuchâtel Knights W | 7 - 18 | NFFL Women |
