| Datum | Home | Away | Resultat | Liga |
|---|---|---|---|---|
| 12.12.2021 |  New York Jets |  New Orleans Saints | 9 - 30 | NFL |
| 12.12.2021 |  Kansas City Chiefs |  Las Vegas Raiders | 48 - 9 | NFL |
| 12.12.2021 |  Houston Texans |  Seattle Seahawks | 13 - 33 | NFL |
| 12.12.2021 |  Cleveland Browns |  Baltimore Ravens | 24 - 22 | NFL |
| 12.12.2021 |  Cincinnati Bengals |  San Francisco 49ers | 23 - 26 | NFL |
| 12.12.2021 |  Carolina Panthers |  Atlanta Falcons | 21 - 29 | NFL |
| 12.12.2021 |  Green Bay Packers |  Chicago Bears | 45 - 30 | NFL |
| 09.12.2021 |  Minnesota Vikings |  Pittsburgh Steelers | 36 - 28 | NFL |
| 06.12.2021 |  Buffalo Bills |  New England Patriots | 10 - 14 | NFL |
| 05.12.2021 | Pittsburgh Steelers | Baltimore Ravens | 20 - 19 | NFL |
| 05.12.2021 |  Los Angeles Rams |  Jacksonville Jaguars | 37 - 7 | NFL |
| 05.12.2021 | Las Vegas Raiders |  Washington Commanders | 15 - 17 | NFL |
| 05.12.2021 | New York Jets |  Philadelphia Eagles | 18 - 33 | NFL |
| 05.12.2021 |  Miami Dolphins |  New York Giants | 20 - 9 | NFL |
| 05.12.2021 | Kansas City Chiefs |  Denver Broncos | 22 - 9 | NFL |
| 05.12.2021 | Houston Texans |  Indianapolis Colts | 0 - 31 | NFL |
| 05.12.2021 |  Detroit Lions | Minnesota Vikings | 29 - 27 | NFL |
| 05.12.2021 | Cincinnati Bengals |  Los Angeles Chargers | 22 - 41 | NFL |
| 05.12.2021 | Chicago Bears |  Arizona Cardinals | 22 - 33 | NFL |
| 05.12.2021 | Atlanta Falcons |  Tampa Bay Buccaneers | 17 - 30 | NFL |
| 05.12.2021 | Seattle Seahawks | San Francisco 49ers | 30 - 23 | NFL |
| 02.12.2021 | New Orleans Saints |  Dallas Cowboys | 17 - 27 | NFL |
| 29.11.2021 | Washington Commanders | Seattle Seahawks | 17 - 15 | NFL |
| 28.11.2021 | San Francisco 49ers | Minnesota Vikings | 34 - 26 | NFL |
| 28.11.2021 | Green Bay Packers | Los Angeles Rams | 36 - 28 | NFL |
| 28.11.2021 | Denver Broncos | Los Angeles Chargers | 28 - 13 | NFL |
| 28.11.2021 | New York Giants | Philadelphia Eagles | 13 - 7 | NFL |
| 28.11.2021 | New England Patriots |  Tennessee Titans | 36 - 13 | NFL |
| 28.11.2021 | Miami Dolphins | Carolina Panthers | 33 - 10 | NFL |
| 28.11.2021 | Jacksonville Jaguars | Atlanta Falcons | 14 - 21 | NFL |
| 28.11.2021 | Indianapolis Colts | Tampa Bay Buccaneers | 31 - 38 | NFL |
| 28.11.2021 | Houston Texans | New York Jets | 14 - 21 | NFL |
| 28.11.2021 | Cincinnati Bengals | Pittsburgh Steelers | 41 - 10 | NFL |
| 28.11.2021 | Baltimore Ravens | Cleveland Browns | 16 - 10 | NFL |
| 25.11.2021 | Dallas Cowboys | Las Vegas Raiders | 33 - 36 | NFL |
| 25.11.2021 | Detroit Lions | Chicago Bears | 14 - 16 | NFL |
| 25.11.2021 | New Orleans Saints | Buffalo Bills | 6 - 31 | NFL |
| 22.11.2021 | Tampa Bay Buccaneers | New York Giants | 30 - 10 | NFL |
| 21.11.2021 | Seattle Seahawks | Arizona Cardinals | 13 - 23 | NFL |
| 21.11.2021 | Kansas City Chiefs | Dallas Cowboys | 19 - 9 | NFL |
| 21.11.2021 | Las Vegas Raiders | Cincinnati Bengals | 13 - 32 | NFL |
| 21.11.2021 | Tennessee Titans | Houston Texans | 13 - 22 | NFL |
| 21.11.2021 | Philadelphia Eagles | New Orleans Saints | 40 - 29 | NFL |
| 21.11.2021 | New York Jets | Miami Dolphins | 17 - 24 | NFL |
| 21.11.2021 | Minnesota Vikings | Green Bay Packers | 34 - 31 | NFL |
| 21.11.2021 | Jacksonville Jaguars | San Francisco 49ers | 10 - 30 | NFL |
| 21.11.2021 | Cleveland Browns | Detroit Lions | 13 - 10 | NFL |
| 21.11.2021 | Chicago Bears | Baltimore Ravens | 13 - 16 | NFL |
| 21.11.2021 | Carolina Panthers | Washington Commanders | 21 - 27 | NFL |
| 21.11.2021 | Buffalo Bills | Indianapolis Colts | 15 - 41 | NFL |
