| Datum | Home | Away | Resultat | Liga |
|---|---|---|---|---|
| 24.10.2021 |  Los Angeles Rams |  Detroit Lions | 28 - 19 | NFL |
| 24.10.2021 |  Tennessee Titans |  Kansas City Chiefs | 27 - 3 | NFL |
| 24.10.2021 |  New York Giants |  Carolina Panthers | 25 - 3 | NFL |
| 24.10.2021 |  New England Patriots |  New York Jets | 54 - 13 | NFL |
| 24.10.2021 |  Miami Dolphins |  Atlanta Falcons | 28 - 30 | NFL |
| 24.10.2021 |  Green Bay Packers |  Washington Commanders | 24 - 10 | NFL |
| 24.10.2021 |  Baltimore Ravens |  Cincinnati Bengals | 17 - 41 | NFL |
| 24.10.2021 |  Schaffhausen Sharks |  LUCAF Owls | 13 - 25 | NLC |
| 24.10.2021 |  Calanda Broncos |  Zurich Renegades | 12 - 8 | U16 |
| 24.10.2021 |  San Francisco 49ers |  Indianapolis Colts | 18 - 30 | NFL |
| 23.10.2021 |  Thun Tigers |  Bienna Jets | 20 - 14 | NLB |
| 23.10.2021 |  Argovia Pirates |  Luzern Lions | 0 - 12 | U19 Challenge League |
| 22.10.2021 |  Cleveland Browns |  Denver Broncos | 17 - 14 | NFL |
| 18.10.2021 |  Pittsburgh Steelers |  Seattle Seahawks | 23 - 20 | NFL |
| 18.10.2021 | Tennessee Titans |  Buffalo Bills | 34 - 31 | NFL |
| 17.10.2021 | New England Patriots |  Dallas Cowboys | 29 - 35 | NFL |
| 17.10.2021 | Denver Broncos |  Las Vegas Raiders | 24 - 34 | NFL |
| 17.10.2021 | Cleveland Browns |  Arizona Cardinals | 14 - 37 | NFL |
| 17.10.2021 | Washington Commanders | Kansas City Chiefs | 13 - 31 | NFL |
| 17.10.2021 | New York Giants | Los Angeles Rams | 11 - 38 | NFL |
| 17.10.2021 | Indianapolis Colts |  Houston Texans | 31 - 3 | NFL |
| 17.10.2021 | Detroit Lions | Cincinnati Bengals | 11 - 34 | NFL |
| 17.10.2021 |  Chicago Bears | Green Bay Packers | 14 - 24 | NFL |
| 17.10.2021 | Carolina Panthers |  Minnesota Vikings | 28 - 34 | NFL |
| 17.10.2021 | Baltimore Ravens |  Los Angeles Chargers | 34 - 6 | NFL |
| 17.10.2021 |  Jacksonville Jaguars | Miami Dolphins | 23 - 20 | NFL |
| 17.10.2021 | Schaffhausen Sharks |  Morges Bandits | 32 - 12 | NLC |
| 17.10.2021 | LUCAF Owls |  Langenthal Invaders | 24 - 8 | NLC |
| 17.10.2021 |  St. Gallen Bears | Bienna Jets | 14 - 27 | NLB |
| 17.10.2021 | Calanda Broncos |  Bern Grizzlies | 64 - 6 | U16 |
| 16.10.2021 | Thun Tigers | Luzern Lions | 55 - 7 | NLB |
| 16.10.2021 | Thun Tigers | Zurich Renegades | 0 - 28 | U16 |
| 16.10.2021 | Argovia Pirates |  Lugano Rebels | 58 - 6 | U19 Challenge League |
| 14.10.2021 |  Philadelphia Eagles |  Tampa Bay Buccaneers | 22 - 28 | NFL |
| 11.10.2021 | Baltimore Ravens | Indianapolis Colts | 31 - 25 | NFL |
| 10.10.2021 | Dallas Cowboys | New York Giants | 44 - 20 | NFL |
| 10.10.2021 | Arizona Cardinals | San Francisco 49ers | 17 - 10 | NFL |
| 10.10.2021 | Las Vegas Raiders | Chicago Bears | 9 - 20 | NFL |
| 10.10.2021 | Los Angeles Chargers | Cleveland Browns | 47 - 42 | NFL |
| 10.10.2021 | Washington Commanders |  New Orleans Saints | 22 - 33 | NFL |
| 10.10.2021 | Tampa Bay Buccaneers | Miami Dolphins | 45 - 17 | NFL |
| 10.10.2021 | Pittsburgh Steelers | Denver Broncos | 27 - 19 | NFL |
| 10.10.2021 | Minnesota Vikings | Detroit Lions | 19 - 17 | NFL |
| 10.10.2021 | Jacksonville Jaguars | Tennessee Titans | 19 - 37 | NFL |
| 10.10.2021 | Houston Texans | New England Patriots | 22 - 25 | NFL |
| 10.10.2021 | Cincinnati Bengals | Green Bay Packers | 22 - 25 | NFL |
| 10.10.2021 | Carolina Panthers | Philadelphia Eagles | 18 - 21 | NFL |
| 10.10.2021 | Atlanta Falcons | New York Jets | 27 - 20 | NFL |
| 10.10.2021 | LUCAF Owls | Morges Bandits | 26 - 11 | NLC |
| 10.10.2021 | St. Gallen Bears |  Geneva Whoppers | 50 - 0 | NLB |
