| Datum | Home | Away | Resultat | Liga |
|---|---|---|---|---|
| 10.10.2021 |  Bienna Jets |  Argovia Pirates | 20 - 3 | NLB |
| 10.10.2021 |  Glarus Orks |  Emmen Dragons | 18 - 0 | NLC |
| 10.10.2021 |  Winterthur Warriors |  Zurich Renegades | 0 - 46 | U16 |
| 10.10.2021 |  Bern Grizzlies |  Thun Tigers | 14 - 32 | U16 |
| 10.10.2021 |  Kansas City Chiefs |  Buffalo Bills | 20 - 38 | NFL |
| 09.10.2021 |  Luzern Lions | Argovia Pirates | 34 - 3 | NLB |
| 09.10.2021 | Thun Tigers |  Lugano Rebels | 56 - 0 | NLB |
| 09.10.2021 |  Calanda Broncos |  Basel Gladiators | 62 - 6 | U16 |
| 07.10.2021 |  Seattle Seahawks |  Los Angeles Rams | 17 - 26 | NFL |
| 05.10.2021 |  Los Angeles Chargers |  Las Vegas Raiders | 28 - 14 | NFL |
| 04.10.2021 |  New England Patriots |  Tampa Bay Buccaneers | 17 - 19 | NFL |
| 03.10.2021 |  Green Bay Packers |  Pittsburgh Steelers | 27 - 17 | NFL |
| 03.10.2021 |  Denver Broncos |  Baltimore Ravens | 7 - 23 | NFL |
| 03.10.2021 |  San Francisco 49ers | Seattle Seahawks | 21 - 28 | NFL |
| 03.10.2021 | Los Angeles Rams |  Arizona Cardinals | 20 - 37 | NFL |
| 03.10.2021 |  Philadelphia Eagles | Kansas City Chiefs | 30 - 42 | NFL |
| 03.10.2021 |  New York Jets |  Tennessee Titans | 27 - 24 | NFL |
| 03.10.2021 |  New Orleans Saints |  New York Giants | 21 - 27 | NFL |
| 03.10.2021 |  Minnesota Vikings |  Cleveland Browns | 7 - 14 | NFL |
| 03.10.2021 |  Miami Dolphins |  Indianapolis Colts | 17 - 27 | NFL |
| 03.10.2021 |  Dallas Cowboys |  Carolina Panthers | 36 - 28 | NFL |
| 03.10.2021 |  Chicago Bears |  Detroit Lions | 24 - 14 | NFL |
| 03.10.2021 | Buffalo Bills |  Houston Texans | 40 - 0 | NFL |
| 03.10.2021 |  Atlanta Falcons |  Washington Commanders | 30 - 34 | NFL |
| 03.10.2021 |  Niederbipp Ducks |  LUCAF Owls | 0 - 51 | NLC |
| 03.10.2021 |  Zofingen Cheetahs | Emmen Dragons | 6 - 63 | NLC |
| 03.10.2021 |  Schaffhausen Sharks |  Neuchatel Knights | 27 - 3 | NLC |
| 02.10.2021 | Calanda Broncos | Bern Grizzlies | 21 - 12 | NLA |
| 02.10.2021 | Calanda Broncos | Basel Gladiators | 21 - 6 | U19 Elite |
| 30.09.2021 |  Cincinnati Bengals |  Jacksonville Jaguars | 24 - 21 | NFL |
| 27.09.2021 | San Francisco 49ers | Green Bay Packers | 28 - 30 | NFL |
| 27.09.2021 | Dallas Cowboys | Philadelphia Eagles | 41 - 21 | NFL |
| 26.09.2021 | Minnesota Vikings | Seattle Seahawks | 30 - 17 | NFL |
| 26.09.2021 | Los Angeles Rams | Tampa Bay Buccaneers | 34 - 24 | NFL |
| 26.09.2021 | Las Vegas Raiders | Miami Dolphins | 31 - 28 | NFL |
| 26.09.2021 | Denver Broncos | New York Jets | 26 - 0 | NFL |
| 26.09.2021 | Tennessee Titans | Indianapolis Colts | 25 - 16 | NFL |
| 26.09.2021 | Pittsburgh Steelers | Cincinnati Bengals | 10 - 24 | NFL |
| 26.09.2021 | New York Giants | Atlanta Falcons | 14 - 17 | NFL |
| 26.09.2021 | New England Patriots | New Orleans Saints | 13 - 28 | NFL |
| 26.09.2021 | Kansas City Chiefs | Los Angeles Chargers | 24 - 30 | NFL |
| 26.09.2021 | Jacksonville Jaguars | Arizona Cardinals | 19 - 31 | NFL |
| 26.09.2021 | Detroit Lions | Baltimore Ravens | 17 - 19 | NFL |
| 26.09.2021 | Cleveland Browns | Chicago Bears | 26 - 6 | NFL |
| 26.09.2021 | Buffalo Bills | Washington Commanders | 43 - 21 | NFL |
| 26.09.2021 |  Hamburg Sea Devils |  Frankfurt Galaxy | 30 - 32 | ELF |
| 26.09.2021 | Bern Grizzlies |  Geneva Seahawks | 21 - 16 | NLA |
| 26.09.2021 | Thun Tigers |  Fribourg Cardinals | 56 - 6 | NLB |
| 26.09.2021 | Lugano Rebels |  St. Gallen Bears | 6 - 27 | NLB |
| 26.09.2021 | Luzern Lions | Argovia Pirates | 23 - 15 | NLB |
