| Datum | Home | Away | Resultat | Liga |
|---|---|---|---|---|
| 26.09.2021 |  Geneva Whoppers |  Bienna Jets | 24 - 60 | NLB |
| 26.09.2021 |  Calanda Broncos |  Zurich Renegades | 16 - 20 | U16 |
| 26.09.2021 | Zurich Renegades |  Basel Gladiators | 14 - 24 | U19 Elite |
| 26.09.2021 |  Luzern Lions |  Riviera Saints | 52 - 0 | U19 Challenge League |
| 25.09.2021 | Calanda Broncos |  Winterthur Warriors | 35 - 8 | NLA |
| 25.09.2021 |  Zurich State Spartans |  Glarus Orks | 55 - 15 | NLC |
| 25.09.2021 |  Langenthal Invaders |  Schaffhausen Sharks | 8 - 29 | NLC |
| 25.09.2021 | Calanda Broncos |  Bern Grizzlies | 25 - 8 | U19 Elite |
| 25.09.2021 |  Geneva Seahawks |  Thun Tigers | 18 - 32 | U16 |
| 23.09.2021 |  Houston Texans |  Carolina Panthers | 9 - 24 | NFL |
| 21.09.2021 |  Green Bay Packers |  Detroit Lions | 35 - 17 | NFL |
| 20.09.2021 |  Baltimore Ravens |  Kansas City Chiefs | 36 - 35 | NFL |
| 19.09.2021 |  Seattle Seahawks |  Tennessee Titans | 30 - 33 | NFL |
| 19.09.2021 |  Los Angeles Chargers |  Dallas Cowboys | 17 - 20 | NFL |
| 19.09.2021 |  Tampa Bay Buccaneers |  Atlanta Falcons | 48 - 25 | NFL |
| 19.09.2021 |  Arizona Cardinals |  Minnesota Vikings | 34 - 33 | NFL |
| 19.09.2021 |  Pittsburgh Steelers |  Las Vegas Raiders | 17 - 26 | NFL |
| 19.09.2021 |  Philadelphia Eagles |  San Francisco 49ers | 11 - 17 | NFL |
| 19.09.2021 |  New York Jets |  New England Patriots | 6 - 25 | NFL |
| 19.09.2021 |  Miami Dolphins |  Buffalo Bills | 0 - 35 | NFL |
| 19.09.2021 |  Jacksonville Jaguars |  Denver Broncos | 13 - 23 | NFL |
| 19.09.2021 |  Indianapolis Colts |  Los Angeles Rams | 24 - 27 | NFL |
| 19.09.2021 |  Cleveland Browns | Houston Texans | 31 - 21 | NFL |
| 19.09.2021 |  Chicago Bears |  Cincinnati Bengals | 20 - 17 | NFL |
| 19.09.2021 | Carolina Panthers |  New Orleans Saints | 26 - 7 | NFL |
| 19.09.2021 | Zurich State Spartans | Langenthal Invaders | 24 - 33 | NLC |
| 19.09.2021 |  Fribourg Cardinals | Bienna Jets | 20 - 22 | NLB |
| 19.09.2021 |  Emmen Dragons |  Niederbipp Ducks | 42 - 6 | NLC |
| 19.09.2021 |  Lugano Rebels | Luzern Lions | 0 - 0 | NLB |
| 19.09.2021 | Geneva Whoppers | Thun Tigers | 7 - 55 | NLB |
| 19.09.2021 | Geneva Seahawks | Bern Grizzlies | ? - ? | U16 |
| 19.09.2021 | Lugano Rebels | Luzern Lions | ? - ? | U19 Challenge League |
| 18.09.2021 | Basel Gladiators | Winterthur Warriors | 35 - 21 | U19 Elite |
| 18.09.2021 | Thun Tigers | Bern Grizzlies | 20 - 40 | U19 Elite |
| 18.09.2021 | Glarus Orks |  LUCAF Owls | 21 - 32 | NLC |
| 18.09.2021 |  Argovia Pirates |  St. Gallen Bears | 9 - 29 | NLB |
| 18.09.2021 | Zurich Renegades | Winterthur Warriors | 34 - 12 | U16 |
| 18.09.2021 | Basel Gladiators | Calanda Broncos | 44 - 0 | U16 |
| 18.09.2021 | Zurich Renegades | Geneva Seahawks | 7 - 10 | NLA |
| 16.09.2021 |  Washington Commanders |  New York Giants | 30 - 29 | NFL |
| 14.09.2021 | Las Vegas Raiders | Baltimore Ravens | 33 - 27 | NFL |
| 13.09.2021 | Los Angeles Rams | Chicago Bears | 34 - 14 | NFL |
| 12.09.2021 | New York Giants | Denver Broncos | 13 - 27 | NFL |
| 12.09.2021 | New Orleans Saints | Green Bay Packers | 38 - 3 | NFL |
| 12.09.2021 | New England Patriots | Miami Dolphins | 16 - 17 | NFL |
| 12.09.2021 | Kansas City Chiefs | Cleveland Browns | 33 - 29 | NFL |
| 12.09.2021 | Washington Commanders | Los Angeles Chargers | 16 - 20 | NFL |
| 12.09.2021 | Tennessee Titans | Arizona Cardinals | 13 - 38 | NFL |
| 12.09.2021 | Indianapolis Colts | Seattle Seahawks | 16 - 28 | NFL |
| 12.09.2021 | Houston Texans | Jacksonville Jaguars | 37 - 21 | NFL |
