| Datum | Home | Away | Resultat | Liga |
|---|---|---|---|---|
| 12.09.2021 |  Detroit Lions |  San Francisco 49ers | 33 - 41 | NFL |
| 12.09.2021 |  Cincinnati Bengals |  Minnesota Vikings | 27 - 24 | NFL |
| 12.09.2021 |  Carolina Panthers |  New York Jets | 19 - 14 | NFL |
| 12.09.2021 |  Buffalo Bills |  Pittsburgh Steelers | 16 - 23 | NFL |
| 12.09.2021 |  Atlanta Falcons |  Philadelphia Eagles | 6 - 32 | NFL |
| 12.09.2021 |  Geneva Seahawks |  Zurich Renegades | 57 - 6 | NLA |
| 12.09.2021 |  Hamburg Sea Devils |  Wroclaw Panthers | 30 - 27 | ELF |
| 12.09.2021 |  Fribourg Cardinals |  Geneva Whoppers | 41 - 8 | NLB |
| 12.09.2021 |  Zofingen Cheetahs |  Schaffhausen Sharks | 8 - 57 | NLC |
| 12.09.2021 |  Calanda Broncos |  Basel Gladiators | 52 - 14 | NLA |
| 12.09.2021 |  Bern Grizzlies |  Winterthur Warriors | 41 - 3 | NLA |
| 12.09.2021 |  St. Gallen Bears |  Luzern Lions | 2 - 6 | NLB |
| 12.09.2021 | St. Gallen Bears |  Bienna Jets | 50 - 0 | U19 Elite |
| 11.09.2021 | Bienna Jets |  Thun Tigers | 6 - 49 | NLB |
| 11.09.2021 |  Argovia Pirates |  Lugano Rebels | 13 - 22 | NLB |
| 11.09.2021 | Argovia Pirates | Lugano Rebels | 49 - 0 | U19 Challenge League |
| 11.09.2021 |  Frankfurt Galaxy |  Cologne Centurions | 36 - 6 | ELF |
| 09.09.2021 |  Tampa Bay Buccaneers |  Dallas Cowboys | 31 - 29 | NFL |
| 05.09.2021 | Frankfurt Galaxy | Cologne Centurions | 45 - 7 | ELF |
| 05.09.2021 |  Leipzig Kings | Wroclaw Panthers | 13 - 21 | ELF |
| 05.09.2021 |  Stuttgart Surge |  Berlin Thunder | 0 - 38 | ELF |
| 05.09.2021 | Fribourg Cardinals | Thun Tigers | 0 - 55 | NLB |
| 05.09.2021 | Schaffhausen Sharks |  Glarus Orks | 28 - 3 | NLC |
| 05.09.2021 | Bern Grizzlies | Geneva Seahawks | 24 - 14 | NLA |
| 05.09.2021 | Basel Gladiators | Zurich Renegades | 28 - 7 | NLA |
| 05.09.2021 | St. Gallen Bears | Lugano Rebels | 11 - 0 | NLB |
| 05.09.2021 | St. Gallen Bears | Winterthur Warriors | 14 - 27 | U19 Elite |
| 05.09.2021 | Basel Gladiators | Zurich Renegades | 21 - 32 | U19 Elite |
| 05.09.2021 | Bern Grizzlies | Geneva Seahawks | 40 - 38 | U19 Elite |
| 04.09.2021 |  Zurich State Spartans | Zofingen Cheetahs | 49 - 0 | NLC |
| 04.09.2021 |  Morges Bandits |  Neuchatel Knights | 22 - 19 | NLC |
| 04.09.2021 |  Emmen Dragons |  Langenthal Invaders | 20 - 28 | NLC |
| 04.09.2021 |  Riviera Saints | Argovia Pirates | 13 - 37 | U19 Challenge League |
| 04.09.2021 | Calanda Broncos | Thun Tigers | 30 - 25 | U19 Elite |
| 04.09.2021 | Calanda Broncos | Winterthur Warriors | 32 - 12 | U16 |
| 04.09.2021 | Basel Gladiators | Zurich Renegades | 0 - 54 | U16 |
| 04.09.2021 | Bern Grizzlies | Geneva Seahawks | ? - ? | U16 |
| 02.09.2021 | Calanda Broncos | Basel Gladiators | ? - ? | U19 Elite |
| 29.08.2021 | Cologne Centurions | Stuttgart Surge | 19 - 9 | ELF |
| 29.08.2021 | Geneva Seahawks | Calanda Broncos | 28 - 35 | NLA |
| 29.08.2021 | Hamburg Sea Devils | Leipzig Kings | 17 - 18 | ELF |
| 29.08.2021 | Bienna Jets | Fribourg Cardinals | 19 - 0 | NLB |
| 29.08.2021 | Neuchatel Knights |  LUCAF Owls | 3 - 34 | NLC |
| 29.08.2021 | Thun Tigers | Geneva Whoppers | 49 - 0 | NLB |
| 29.08.2021 | St. Gallen Bears | Argovia Pirates | 18 - 0 | NLB |
| 29.08.2021 | Luzern Lions | Lugano Rebels | 41 - 14 | NLB |
| 29.08.2021 | Geneva Seahawks | Calanda Broncos | 8 - 27 | U19 Elite |
| 29.08.2021 | Thun Tigers | Geneva Seahawks | 36 - 22 | U16 |
| 29.08.2021 | St. Gallen Bears | Basel Gladiators | 0 - 49 | U19 Elite |
| 29.08.2021 | Bienna Jets | Zurich Renegades | 0 - 50 | U19 Elite |
