| 2021-08-14 18:00:0014.08.2021 | Argovia Pirates vs Luzern Lions | 18 – 3 |
| 2021-08-15 14:00:0015.08.2021 | Bienna Jets vs Geneva Whoppers | 50 – 0 |
| 2021-08-21 18:00:0021.08.2021 | Lugano Rebels vs Argovia Pirates | 6 – 25 |
| 2021-08-22 14:00:0022.08.2021 | Geneva Whoppers vs Fribourg Cardinals | 6 – 2 |
| 2021-08-22 14:00:0522.08.2021 | Luzern Lions vs St. Gallen Bears | 6 – 13 |
| 2021-08-22 16:00:0022.08.2021 | Thun Tigers vs Bienna Jets | 28 – 19 |
| 2021-08-29 14:00:0029.08.2021 | Luzern Lions vs Lugano Rebels | 41 – 14 |
| 2021-08-29 14:00:0029.08.2021 | St. Gallen Bears vs Argovia Pirates | 18 – 0 |
| 2021-08-29 14:00:0029.08.2021 | Thun Tigers vs Geneva Whoppers | 49 – 0 |
| 2021-08-29 14:00:0029.08.2021 | Bienna Jets vs Fribourg Cardinals | 19 – 0 |
| 2021-09-05 14:00:0005.09.2021 | Fribourg Cardinals vs Thun Tigers | 0 – 55 |
| 2021-09-05 14:00:0005.09.2021 | St. Gallen Bears vs Lugano Rebels | 11 – 0 |
| 2021-09-11 18:00:0011.09.2021 | Argovia Pirates vs Lugano Rebels | 13 – 22 |
| 2021-09-11 18:00:0011.09.2021 | Bienna Jets vs Thun Tigers | 6 – 49 |
| 2021-09-12 14:00:0012.09.2021 | Fribourg Cardinals vs Geneva Whoppers | 41 – 8 |
| 2021-09-12 14:00:0012.09.2021 | St. Gallen Bears vs Luzern Lions | 2 – 6 |
| 2021-09-18 18:00:0018.09.2021 | Argovia Pirates vs St. Gallen Bears | 9 – 29 |
| 2021-09-19 14:00:0019.09.2021 | Fribourg Cardinals vs Bienna Jets | 20 – 22 |
| 2021-09-19 14:00:0019.09.2021 | Geneva Whoppers vs Thun Tigers | 7 – 55 |
| 2021-09-19 14:00:0019.09.2021 | Lugano Rebels vs Luzern Lions | 0 – 0 |
| 2021-09-26 14:00:0026.09.2021 | Thun Tigers vs Fribourg Cardinals | 56 – 6 |
| 2021-09-26 14:00:0026.09.2021 | Geneva Whoppers vs Bienna Jets | 24 – 60 |
| 2021-09-26 14:00:0026.09.2021 | Luzern Lions vs Argovia Pirates | 23 – 15 |
| 2021-09-26 14:00:0026.09.2021 | Lugano Rebels vs St. Gallen Bears | 6 – 27 |
| 2021-10-09 18:00:1209.10.2021 | 1/4-Final: Thun Tigers vs Lugano Rebels | 56 – 0 |
| 2021-10-09 18:00:2509.10.2021 | 1/4-Final: Luzern Lions vs Argovia Pirates | 34 – 3 |
| 2021-10-10 14:00:0410.10.2021 | 1/4-Final: Bienna Jets vs Argovia Pirates | 20 – 3 |
| 2021-10-10 14:00:3110.10.2021 | 1/4-Final: St. Gallen Bears vs Geneva Whoppers | 50 – 0 |
| 2021-10-16 18:00:1716.10.2021 | 1/2-Finale: Thun Tigers vs Luzern Lions | 55 – 7 |
| 2021-10-17 14:00:1117.10.2021 | 1/2-Finale: St. Gallen Bears vs Bienna Jets | 14 – 27 |
| 2021-10-23 17:00:5323.10.2021 | NLB Finale: Thun Tigers vs Bienna Jets | 17:00:5317:00 |
