| 2021-07-24 18:00:0024.07.2021 | Orks | 57 – 0 | Zofingen Cheetahs | N/A |
| 2021-07-24 18:00:0024.07.2021 | Langenthal Invaders | 41 – 0 | Zurich State Spartans | N/A |
| 2021-07-25 14:00:0025.07.2021 | Dragons | 6 – 14 | Schaffhausen Sharks | N/A |
| 2021-07-25 14:00:0025.07.2021 | Niederbipp Ducks | 0 – 28 | Morges Bandits | N/A |
| 2021-07-31 18:00:0031.07.2021 | Niederbipp Ducks | 0 – 34 | Neuchatel Knights | N/A |
| 2021-08-07 18:00:0007.08.2021 | Langenthal Invaders | 50 – 20 | Morges Bandits | N/A |
| 2021-08-15 14:00:0015.08.2021 | LUCAF Owls | 29 – 18 | Dragons | N/A |
| 2021-08-15 14:00:0015.08.2021 | Morges Bandits | 30 – 16 | Orks | N/A |
| 2021-08-15 14:00:0015.08.2021 | Neuchatel Knights | 7 – 6 | Zurich State Spartans | N/A |
| 2021-08-15 14:00:0015.08.2021 | Niederbipp Ducks | 37 – 0 | Zofingen Cheetahs | N/A |
| 2021-08-21 18:00:0021.08.2021 | Zofingen Cheetahs | 0 – 70 | Langenthal Invaders | N/A |
| 2021-08-22 14:00:0022.08.2021 | Schaffhausen Sharks | 25 – 0 | Zurich State Spartans | N/A |
| 2021-08-28 18:00:0028.08.2021 | Dragons | 36 – 13 | Zurich State Spartans | N/A |
| 2021-08-28 18:00:0028.08.2021 | Orks | 13 – 48 | Langenthal Invaders | N/A |
| 2021-08-28 18:00:0028.08.2021 | Zofingen Cheetahs | 0 – 63 | Schaffhausen Sharks | N/A |
| 2021-08-29 14:00:0029.08.2021 | Neuchatel Knights | 3 – 34 | LUCAF Owls | N/A |
| 2021-09-04 18:00:0004.09.2021 | Dragons | 20 – 28 | Langenthal Invaders | N/A |
| 2021-09-04 18:00:0004.09.2021 | Morges Bandits | 22 – 19 | Neuchatel Knights | N/A |
| 2021-09-04 18:00:0004.09.2021 | Zurich State Spartans | 49 – 0 | Zofingen Cheetahs | N/A |
| 2021-09-05 14:00:0005.09.2021 | Schaffhausen Sharks | 28 – 3 | Orks | N/A |
| 2021-09-12 14:00:0012.09.2021 | Zofingen Cheetahs | 8 – 57 | Schaffhausen Sharks | N/A |
| 2021-09-18 18:00:0018.09.2021 | Orks | 21 – 32 | LUCAF Owls | N/A |
| 2021-09-19 14:00:0019.09.2021 | Dragons | 42 – 6 | Niederbipp Ducks | N/A |
| 2021-09-19 14:00:4919.09.2021 | Zurich State Spartans | 24 – 33 | Langenthal Invaders | N/A |
| 2021-09-25 18:00:0025.09.2021 | Langenthal Invaders | 8 – 29 | Schaffhausen Sharks | N/A |
| 2021-09-25 18:00:0025.09.2021 | Zurich State Spartans | 55 – 15 | Orks | N/A |
| 2021-10-03 14:00:0003.10.2021 | Schaffhausen Sharks | 27 – 3 | Neuchatel Knights | N/A |
| 2021-10-03 14:00:0003.10.2021 | Zofingen Cheetahs | 6 – 63 | Dragons | N/A |
| 2021-10-03 14:00:0003.10.2021 | Niederbipp Ducks | 0 – 51 | LUCAF Owls | N/A |
| 2021-10-10 14:00:0010.10.2021 | Orks | 18 – 0 | Dragons | N/A |
| 2021-10-10 14:00:4910.10.2021 | LUCAF Owls | 26 – 11 | Morges Bandits | N/A |
| 2021-10-17 14:00:1117.10.2021 | LUCAF Owls | 24 – 8 | Langenthal Invaders | N/A |
| 2021-10-17 14:00:2417.10.2021 | Schaffhausen Sharks | 32 – 12 | Morges Bandits | N/A |
| 2021-10-24 14:00:0624.10.2021 | Schaffhausen Sharks | 13 – 25 | LUCAF Owls | N/A |
LUCAF Owls
Geneva Whoppers
Morges Bandits
Neuchatel Knights
Fribourg Cardinals
Zurich State Spartans
Dragons
Orks
Lugano Rebels
Niederbipp Ducks