| 2021-05-15 16:00:0015.05.2021 |   Vienna Vikings vs Kragujevac Wild Boars | 82 – 7 | CEFL | – |
| 2021-05-15 18:00:0015.05.2021 |   Swarco Raiders vs MIlan Seamen | 41 – 14 | CEFL | – |
| 2021-05-22 00:00:0022.05.2021 |   Schwäbisch Hall Unicorns vs Carlstad Crusaders | 00:00:00Abgesagt | CEFL | – |
| 2021-05-29 15:00:0029.05.2021 |   Bern Grizzlies vs Bienna Jets | 42 – 43 | U19 Elite | 1 |
| 2021-05-29 16:00:0029.05.2021 | SWARCO Raiders vs Vikings | 20 – 13 | CEFL | – |
| 2021-05-29 18:00:0029.05.2021 |   Calanda Broncos vs St. Gallen Bears | 21 – 20 | U19 Elite | 1 |
| 2021-05-29 18:00:0029.05.2021 |  Calanda Broncos vs Fehervar Enthroners | 18:00:00Abgesagt | CEFL | – |
| 2021-05-30 11:00:0030.05.2021 |   Gladiators vs Tigers | 35 – 20 | U19 Elite | 1 |
| 2021-06-05 14:00:5305.06.2021 |  Saarland Hurricanes Juniors vs Gladiators U19 | 0 – 34 | Friendly | – |
| 2021-06-05 15:00:0005.06.2021 |  Winterthur Warriors vs Thun Tigers | 7 – 14 | U19 Elite | 2 |
| 2021-06-06 11:00:0006.06.2021 |  Zurich Renegades vs Bern Grizzlies | 35 – 20 | U19 Elite | 2 |
| 2021-06-06 12:00:0006.06.2021 |  Geneva Seahawks vs St. Gallen Bears | 46 – 14 | U19 Elite | 2 |
| 2021-06-13 11:00:0013.06.2021 | Zurich Renegades vs St. Gallen Bears | 32 – 3 | U19 Elite | 3 |
| 2021-06-13 14:00:0013.06.2021 | Bienna Jets vs Winterthur Warriors | 6 – 32 | U19 Elite | 3 |
| 2021-06-13 14:00:0013.06.2021 | Thun Tigers vs Geneva Seahawks | 19 – 14 | U19 Elite | 3 |
| 2021-06-13 15:00:0013.06.2021 | Calanda Broncos vs Schwäbisch Hall Unicorns | 21 – 35 | CEFL | – |
| 2021-06-19 18:00:0019.06.2021 |   Wroclaw Panthers vs Cologne Centurions | 55 – 39 | ELF, North, South | 1 |
| 2021-06-19 18:00:0019.06.2021 | Winterthur Warriors vs Zurich Renegades | 32 – 0 | NLA | 4 |
| 2021-06-19 19:00:0019.06.2021 |   Barcelona Dragons vs Stuttgart Surge | 17 – 21 | ELF, North, South | 1 |
| 2021-06-20 11:00:0020.06.2021 | Basel Gladiators vs Winterthur Warriors | 28 – 8 | U19 Elite | 4 |
| 2021-06-20 11:00:0020.06.2021 | Calanda Broncos vs Bienna Jets | 42 – 20 | U19 Elite | 4 |
| 2021-06-20 11:00:0020.06.2021 | St. Gallen Bears vs Bern Grizzlies | 28 – 44 | U19 Elite | 4 |
| 2021-06-20 14:00:0020.06.2021 | Thun Tigers vs Zurich Renegades | 14 – 23 | U19 Elite | 4 |
| 2021-06-20 14:00:0020.06.2021 | Basel Gladiators vs Bern Grizzlies | 22 – 24 | NLA | 4 |
| 2021-06-20 14:00:0020.06.2021 | Calanda Broncos vs Geneva Seahawks | 31 – 0 | NLA | 4 |
| 2021-06-20 15:00:0020.06.2021 |   Hamburg Sea Devils vs Frankfurt Galaxy | 17 – 15 | ELF, North, South | 1 |
| 2021-06-20 15:00:0020.06.2021 |   Berlin Thunder vs Leipzig Kings | 27 – 37 | ELF, North, South | 1 |
| 2021-06-26 15:00:0026.06.2021 | CEFL Bowl XV: Swarco Raiders vs. Schwäbisch Hall | 16 – 22 | CEFL | – |
| 2021-06-26 18:00:0026.06.2021 | Wroclaw Panthers vs Leipzig Kings | 54 – 28 | ELF, North, South | 2 |
| 2021-06-26 18:00:0026.06.2021 | Winterthur Warriors vs Calanda Broncos | 6 – 31 | NLA | 5 |
| 2021-06-27 14:00:0027.06.2021 | Zurich Renegades vs Basel Gladiators | 19 – 21 | NLA | 5 |
| 2021-06-27 15:00:0027.06.2021 | Cologne Centurions vs Barcelona Dragons | 40 – 12 | ELF, North, South | 2 |
| 2021-06-27 15:00:0027.06.2021 | Stuttgart Surge vs Frankfurt Galaxy | 20 – 42 | ELF, North, South | 2 |
| 2021-06-27 15:00:4727.06.2021 |  U19 Friendly: Freiburg Sacristans vs Basel Gladiators | 6 – 17 | Friendly | – |
| 2021-07-03 15:00:0003.07.2021 | Bern Grizzlies vs Basel Gladiators | 20 – 13 | U19 Elite | 6 |
| 2021-07-03 15:00:0003.07.2021 | Calanda Broncos vs Zurich Renegades | 30 – 7 | U19 Elite | 6 |
| 2021-07-03 18:00:0003.07.2021 | Bern Grizzlies vs Basel Gladiators | 55 – 21 | NLA | 6 |
| 2021-07-03 18:00:0003.07.2021 | Calanda Broncos vs Zurich Renegades | 46 – 0 | NLA | 6 |
| 2021-07-03 19:00:0003.07.2021 | Barcelona Dragons vs Hamburg Sea Devils | 14 – 32 | ELF, North, South | 3 |
| 2021-07-04 11:00:0004.07.2021 | Geneva Seahawks vs Bienna Jets | 34 – 21 | U19 Elite | 6 |
| 2021-07-04 11:00:0004.07.2021 | Thun Tigers vs St. Gallen Bears | 28 – 3 | U19 Elite | 6 |
| 2021-07-04 15:00:0004.07.2021 | Leipzig Kings vs Cologne Centurions | 47 – 48 | ELF, North, South | 3 |
| 2021-07-04 15:00:0004.07.2021 | Frankfurt Galaxy vs Wroclaw Panthers | 22 – 13 | ELF, North, South | 3 |
| 2021-07-04 15:00:0004.07.2021 | Berlin Thunder vs Stuttgart Surge | 40 – 19 | ELF, North, South | 3 |
| 2021-07-04 15:00:0004.07.2021 | Geneva Seahawks vs Winterthur Warriors | 35 – 6 | NLA | 6 |
| 2021-07-10 15:00:0010.07.2021 | Bienna Jets vs Thun Tigers | 21 – 26 | U19 Elite | 7 |
| 2021-07-11 11:00:0011.07.2021 | Bern Grizzlies vs Calanda Broncos | 8 – 41 | U19 Elite | 7 |
| 2021-07-11 11:00:0011.07.2021 | Geneva Seahawks vs Basel Gladiators | 22 – 27 | U19 Elite | 7 |
| 2021-07-11 11:00:0011.07.2021 | Zurich Renegades vs Winterthur Warriors | 23 – 0 | U19 Elite | 7 |
| 2021-07-11 14:00:0011.07.2021 | Bern Grizzlies vs Calanda Broncos | 26 – 21 | NLA | 7 |
| 2021-07-11 14:00:0011.07.2021 | Geneva Seahawks vs Basel Gladiators | 69 – 21 | NLA | 7 |
| 2021-07-11 14:00:0011.07.2021 | Zurich Renegades vs Winterthur Warriors | 10 – 35 | NLA | 7 |
| 2021-07-11 15:00:0011.07.2021 | Cologne Centurions vs Frankfurt Galaxy | 20 – 41 | ELF, North, South | 4 |
| 2021-07-11 15:00:0011.07.2021 | Stuttgart Surge vs Leipzig Kings | 27 – 24 | ELF, North, South | 4 |
| 2021-07-11 18:00:0011.07.2021 | Hamburg Sea Devils vs Berlin Thunder | 44 – 6 | ELF, North, South | 4 |
| 2021-07-17 15:00:0017.07.2021 | Basel Gladiators vs Calanda Broncos | 7 – 16 | U19 Elite | 8 |
| 2021-07-17 15:00:0017.07.2021 | Winterthur Warriors vs Geneva Seahawks | 32 – 6 | U19 Elite | 8 |
| 2021-07-17 15:00:0017.07.2021 | Frankfurt Galaxy vs Barcelona Dragons | 42 – 22 | ELF, North, South | 5 |
| 2021-07-17 18:00:0017.07.2021 | Basel Gladiators vs Calanda Broncos | 22 – 48 | NLA | 8 |
| 2021-07-17 18:00:0017.07.2021 | Winterthur Warriors vs Geneva Seahawks | 17 – 33 | NLA | 8 |
| 2021-07-18 14:00:0018.07.2021 | Zurich Renegades vs Bern Grizzlies | 0 – 49 | NLA | 8 |
| 2021-07-18 15:00:0018.07.2021 | Berlin Thunder vs Wroclaw Panthers | 26 – 45 | ELF, North, South | 5 |
| 2021-07-18 15:00:0018.07.2021 | Leipzig Kings vs Hamburg Sea Devils | 0 – 55 | ELF, North, South | 5 |
| 2021-07-24 15:00:0024.07.2021 | Wroclaw Panthers vs Hamburg Sea Devils | 23 – 26 | ELF, North, South | 6 |
| 2021-07-24 18:00:0024.07.2021 |   Glarus Orks vs Zofingen Cheetahs | 57 – 0 | NLC | 1 |
| 2021-07-24 18:00:0024.07.2021 |   Langenthal Invaders vs Zurich State Spartans | 41 – 0 | NLC | 1 |
| 2021-07-24 19:00:0024.07.2021 | Barcelona Dragons vs Berlin Thunder | 41 – 16 | ELF, North, South | 6 |
| 2021-07-25 14:00:0025.07.2021 |   Emmen Dragons vs Schaffhausen Sharks | 6 – 14 | NLC | 1 |
| 2021-07-25 14:00:0025.07.2021 |   Solothurn Ducks vs Morges Bandits | 0 – 28 | NLC | 1 |
| 2021-07-25 15:00:0025.07.2021 | Stuttgart Surge vs Cologne Centurions | 23 – 39 | ELF, North, South | 6 |
| 2021-07-31 18:00:0031.07.2021 | Hamburg Sea Devils vs Barcelona Dragons | 22 – 17 | ELF, North, South | 7 |
| 2021-07-31 18:00:0031.07.2021 | Glarus Orks vs Emmen Dragons | 18:00:00Verschoben | NLC | 2 |
| 2021-07-31 18:00:0031.07.2021 |  Solothurn Ducks vs Neuchâtel Knights | 0 – 34 | NLC | 2 |
| 2021-08-01 15:00:0001.08.2021 | Cologne Centurions vs Wroclaw Panthers | 33 – 31 | ELF, North, South | 7 |
| 2021-08-01 15:00:0001.08.2021 | Leipzig Kings vs Berlin Thunder | 37 – 24 | ELF, North, South | 7 |
| 2021-08-01 15:00:0001.08.2021 | Frankfurt Galaxy vs Stuttgart Surge | 57 – 3 | ELF, North, South | 7 |
| 2021-08-07 18:00:0007.08.2021 | Langenthal Invaders vs Morges Bandits | 50 – 20 | NLC | 3 |
| 2021-08-07 19:00:0007.08.2021 | Barcelona Dragons vs Cologne Centurions | 60 – 51 | ELF, North, South | 8 |
| 2021-08-08 15:00:0008.08.2021 | Frankfurt Galaxy vs Hamburg Sea Devils | 35 – 9 | ELF, North, South | 8 |
| 2021-08-08 15:00:0008.08.2021 | Leipzig Kings vs Stuttgart Surge | 49 – 23 | ELF, North, South | 8 |
| 2021-08-14 12:00:0014.08.2021 | Winterthur Warriors vs Calanda Broncos | 8 – 36 | U16 | 1 |
| 2021-08-14 13:00:0014.08.2021 | Berlin Thunder vs Hamburg Sea Devils | 20 – 28 | ELF, North, South | 9 |
| 2021-08-14 15:00:0014.08.2021 | Winterthur Warriors vs Calanda Broncos | 12 – 23 | U19 Elite | 9 |
| 2021-08-14 15:00:0014.08.2021 |   Argovia Pirates vs Luzern Lions | 28 – 8 | U19 Challenge League | 3 |
| 2021-08-14 18:00:0014.08.2021 | Argovia Pirates vs Luzern Lions | 18 – 3 | NLB | 1 |
| 2021-08-15 11:00:0015.08.2021 | Bienna Jets vs Basel Gladiators | 14 – 46 | U19 Elite | 9 |
| 2021-08-15 11:00:0015.08.2021 | Zurich Renegades vs Basel Gladiators | 48 – 8 | U16 | 1 |
| 2021-08-15 14:00:0015.08.2021 |  Bienna Jets vs Geneva Whoppers | 14:00:00TBD | NLB | 1 |
| 2021-08-15 14:00:0015.08.2021 | Thun Tigers vs Bern Grizzlies | 50 – 12 | U16 | 1 |
| 2021-08-15 14:00:0015.08.2021 |  LUCAF Owls vs Emmen Dragons | 29 – 18 | NLC | 4 |
| 2021-08-15 14:00:0015.08.2021 | Morges Bandits vs Glarus Orks | 30 – 16 | NLC | 4 |
| 2021-08-15 14:00:0015.08.2021 | Neuchâtel Knights vs Zurich State Spartans | 7 – 6 | NLC | 4 |
| 2021-08-15 14:00:0015.08.2021 | Solothurn Ducks vs Zofingen Cheetahs | 37 – 0 | NLC | 4 |
| 2021-08-15 15:00:0015.08.2021 | Wroclaw Panthers vs Frankfurt Galaxy | 7 – 36 | ELF, North, South | 9 |
| 2021-08-15 15:00:0015.08.2021 | Stuttgart Surge vs Barcelona Dragons | 12 – 30 | ELF, North, South | 9 |
| 2021-08-21 14:00:0021.08.2021 |   Lugano Rebels vs Riviera Saints | 0 – 33 | U19 Challenge League | 4 |
| 2021-08-21 18:00:0021.08.2021 | Cologne Centurions vs Leipzig Kings | 24 – 42 | ELF, North, South | 10 |
| 2021-08-21 18:00:0021.08.2021 | Lugano Rebels vs Argovia Pirates | 6 – 25 | NLB | 2 |
| 2021-08-21 18:00:0021.08.2021 | Calanda Broncos vs Bern Grizzlies | 35 – 10 | NLA | 10 |
| 2021-08-21 18:00:0021.08.2021 | Zofingen Cheetahs vs Langenthal Invaders | 0 – 70 | NLC | 2 |
| 2021-08-22 11:00:0022.08.2021 | Thun Tigers vs Bern Grizzlies | 41 – 14 | U19 Elite | 10 |
| 2021-08-22 11:00:0022.08.2021 | Basel Gladiators vs Winterthur Warriors | 37 – 16 | U16 | 2 |
| 2021-08-22 11:00:0022.08.2021 | Zurich Renegades vs Calanda Broncos | 12 – 20 | U16 | 2 |
| 2021-08-22 14:00:0022.08.2021 | Zurich Renegades vs Geneva Seahawks | 6 – 0 | U19 Elite | 10 |
| 2021-08-22 14:00:0022.08.2021 | Basel Gladiators vs Winterthur Warriors | 13 – 46 | NLA | 10 |
| 2021-08-22 14:00:0022.08.2021 | Schaffhausen Sharks vs Zurich State Spartans | 25 – 0 | NLC | 5 |
| 2021-08-22 14:00:0022.08.2021 |  Geneva Whoppers vs Fribourg Cardinals | 6 – 2 | NLB | – |
| 2021-08-22 14:00:0522.08.2021 | Luzern Lions vs St. Gallen Bears | 6 – 13 | NLB | 2 |
| 2021-08-22 15:00:0022.08.2021 | Hamburg Sea Devils vs Wroclaw Panthers | 24 – 30 | ELF, North, South | 10 |
| 2021-08-22 15:00:0022.08.2021 | Berlin Thunder vs Barcelona Dragons | 19 – 3 | ELF, North, South | 10 |
| 2021-08-22 16:00:0022.08.2021 | Thun Tigers vs Bienna Jets | 28 – 19 | NLB | 2 |
| 2021-08-28 12:00:0028.08.2021 | Winterthur Warriors vs Basel Gladiators | 22 – 20 | U16 | 3 |
| 2021-08-28 15:00:0028.08.2021 | Winterthur Warriors vs Bern Grizzlies | 18 – 46 | U19 Elite | 11 |
| 2021-08-28 18:00:0028.08.2021 | Winterthur Warriors vs Bern Grizzlies | 0 – 17 | NLA | 11 |
| 2021-08-28 18:00:0028.08.2021 | Emmen Dragons vs Zurich State Spartans | 36 – 13 | NLC | 6 |
| 2021-08-28 18:00:0028.08.2021 | Glarus Orks vs Langenthal Invaders | 13 – 48 | NLC | 6 |
| 2021-08-28 18:00:0028.08.2021 | Zofingen Cheetahs vs Schaffhausen Sharks | 0 – 63 | NLC | 6 |
| 2021-08-28 19:00:0028.08.2021 | Barcelona Dragons vs Frankfurt Galaxy | 14 – 22 | ELF, North, South | 11 |
| 2021-08-28 20:00:0028.08.2021 | Wroclaw Panthers vs Berlin Thunder | 35 – 12 | ELF, North, South | 11 |
| 2021-08-29 11:00:0029.08.2021 | Bienna Jets vs Zurich Renegades | 0 – 50 | U19 Elite | 11 |
| 2021-08-29 11:00:0029.08.2021 | St. Gallen Bears vs Basel Gladiators | 0 – 49 | U19 Elite | 11 |
| 2021-08-29 11:00:0029.08.2021 | Thun Tigers vs Geneva Seahawks | 36 – 22 | U16 | 3 |
| 2021-08-29 12:00:0029.08.2021 | Geneva Seahawks vs Calanda Broncos | 8 – 27 | U19 Elite | 11 |
| 2021-08-29 14:00:0029.08.2021 | Luzern Lions vs Lugano Rebels | 41 – 14 | NLB | 3 |
| 2021-08-29 14:00:0029.08.2021 | St. Gallen Bears vs Argovia Pirates | 18 – 0 | NLB | 3 |
| 2021-08-29 14:00:0029.08.2021 | Thun Tigers vs Geneva Whoppers | 49 – 0 | NLB | 3 |
| 2021-08-29 14:00:0029.08.2021 | Neuchâtel Knights vs LUCAF Owls | 3 – 34 | NLC | 6 |
| 2021-08-29 14:00:0029.08.2021 | Bienna Jets vs Fribourg Cardinals | 19 – 0 | NLB | – |
| 2021-08-29 15:00:0029.08.2021 | Hamburg Sea Devils vs Leipzig Kings | 17 – 18 | ELF, North, South | 11 |
| 2021-08-29 15:00:0029.08.2021 | Geneva Seahawks vs Calanda Broncos | 28 – 35 | NLA | 11 |
| 2021-08-29 17:00:0029.08.2021 | Cologne Centurions vs Stuttgart Surge | 19 – 9 | ELF, North, South | 11 |
| 2021-09-04 11:00:0004.09.2021 | Bern Grizzlies vs Geneva Seahawks | 11:00:0011:00 | U16 | 4 |
| 2021-09-04 11:00:0004.09.2021 | Basel Gladiators vs Zurich Renegades | 0 – 54 | U16 | 4 |
| 2021-09-04 12:00:0004.09.2021 | Calanda Broncos vs Winterthur Warriors | 32 – 12 | U16 | 4 |
| 2021-09-04 15:00:0004.09.2021 | Calanda Broncos vs Thun Tigers | 30 – 25 | U19 Elite | 12 |
| 2021-09-04 15:00:0004.09.2021 | Riviera Saints vs Argovia Pirates | 13 – 37 | U19 Challenge League | 6 |
| 2021-09-04 18:00:0004.09.2021 | Emmen Dragons vs Langenthal Invaders | 20 – 28 | NLC | 7 |
| 2021-09-04 18:00:0004.09.2021 | Morges Bandits vs Neuchâtel Knights | 22 – 19 | NLC | 7 |
| 2021-09-04 18:00:0004.09.2021 | Zurich State Spartans vs Zofingen Cheetahs | 49 – 0 | NLC | 7 |
| 2021-09-05 11:00:0005.09.2021 | Bern Grizzlies vs Geneva Seahawks | 40 – 38 | U19 Elite | 12 |
| 2021-09-05 11:00:0005.09.2021 | Basel Gladiators vs Zurich Renegades | 21 – 32 | U19 Elite | 12 |
| 2021-09-05 11:00:0005.09.2021 | St. Gallen Bears vs Winterthur Warriors | 14 – 27 | U19 Elite | 12 |
| 2021-09-05 14:00:0005.09.2021 | St. Gallen Bears vs Lugano Rebels | 11 – 0 | NLB | 4 |
| 2021-09-05 14:00:0005.09.2021 | Basel Gladiators vs Zurich Renegades | 28 – 7 | NLA | 12 |
| 2021-09-05 14:00:0005.09.2021 | Bern Grizzlies vs Geneva Seahawks | 24 – 14 | NLA | 12 |
| 2021-09-05 14:00:0005.09.2021 | Schaffhausen Sharks vs Glarus Orks | 28 – 3 | NLC | 7 |
| 2021-09-05 14:00:0005.09.2021 | Fribourg Cardinals vs Thun Tigers | 0 – 55 | NLB | – |
| 2021-09-05 15:00:0005.09.2021 | Stuttgart Surge vs Berlin Thunder | 0 – 38 | ELF, North, South | 12 |
| 2021-09-05 15:00:0005.09.2021 | Leipzig Kings vs Wroclaw Panthers | 13 – 21 | ELF, North, South | 12 |
| 2021-09-05 15:00:0005.09.2021 | Frankfurt Galaxy vs Cologne Centurions | 45 – 7 | ELF, North, South | 12 |
| 2021-09-09 02:20:0009.09.2021 |   Tampa Bay Buccaneers vs Dallas Cowboys | 31 – 29 | NFL | 1 |
| 2021-09-11 14:45:4411.09.2021 | Frankfurt Galaxy vs Cologne Centurions | 36 – 6 | ELF | – |
| 2021-09-11 15:00:0011.09.2021 | Argovia Pirates vs Lugano Rebels | 49 – 0 | U19 Challenge League | 7 |
| 2021-09-11 18:00:0011.09.2021 | Argovia Pirates vs Lugano Rebels | 13 – 22 | NLB | 5 |
| 2021-09-11 18:00:0011.09.2021 | Bienna Jets vs Thun Tigers | 6 – 49 | NLB | 5 |
| 2021-09-12 11:00:0012.09.2021 | St. Gallen Bears vs Bienna Jets | 50 – 0 | U19 Elite | 10 |
| 2021-09-12 14:00:0012.09.2021 | St. Gallen Bears vs Luzern Lions | 2 – 6 | NLB | 5 |
| 2021-09-12 14:00:0012.09.2021 | Bern Grizzlies vs Winterthur Warriors | 41 – 3 | NLA | 13 |
| 2021-09-12 14:00:0012.09.2021 | Calanda Broncos vs Basel Gladiators | 52 – 14 | NLA | 13 |
| 2021-09-12 14:00:0012.09.2021 | Zofingen Cheetahs vs Schaffhausen Sharks | 8 – 57 | NLC | 3 |
| 2021-09-12 14:00:0012.09.2021 | Fribourg Cardinals vs Geneva Whoppers | 41 – 8 | NLB | – |
| 2021-09-12 14:45:0112.09.2021 | Hamburg Sea Devils vs Wroclaw Panthers | 30 – 27 | ELF | – |
| 2021-09-12 15:00:0012.09.2021 | Geneva Seahawks vs Zurich Renegades | 57 – 6 | NLA | 13 |
| 2021-09-12 19:00:0012.09.2021 |   Atlanta Falcons vs Philadelphia Eagles | 6 – 32 | NFL | 1 |
| 2021-09-12 19:00:0012.09.2021 |   Buffalo Bills vs Pittsburgh Steelers | 16 – 23 | NFL | 1 |
| 2021-09-12 19:00:0012.09.2021 |   Carolina Panthers vs New York Jets | 19 – 14 | NFL | 1 |
| 2021-09-12 19:00:0012.09.2021 |   Cincinnati Bengals vs Minnesota Vikings | 27 – 24 | NFL | 1 |
| 2021-09-12 19:00:0012.09.2021 |   Detroit Lions vs San Francisco 49ers | 33 – 41 | NFL | 1 |
| 2021-09-12 19:00:0012.09.2021 |   Houston Texans vs Jacksonville Jaguars | 37 – 21 | NFL | 1 |
| 2021-09-12 19:00:0012.09.2021 |   Indianapolis Colts vs Seattle Seahawks | 16 – 28 | NFL | 1 |
| 2021-09-12 19:00:0012.09.2021 |   Tennessee Titans vs Arizona Cardinals | 13 – 38 | NFL | 1 |
| 2021-09-12 19:00:0012.09.2021 |   Washington Football Team vs Los Angeles Chargers | 16 – 20 | NFL | 1 |
| 2021-09-12 22:25:0012.09.2021 |   Kansas City Chiefs vs Cleveland Browns | 33 – 29 | NFL | 1 |
| 2021-09-12 22:25:0012.09.2021 |  New England Patriots vs Miami Dolphins | 16 – 17 | NFL | 1 |
| 2021-09-12 22:25:0012.09.2021 |   New Orleans Saints vs Green Bay Packers | 38 – 3 | NFL | 1 |
| 2021-09-12 22:25:0012.09.2021 |   New York Giants vs Denver Broncos | 13 – 27 | NFL | 1 |
| 2021-09-13 02:20:0013.09.2021 |   Los Angeles Rams vs Chicago Bears | 34 – 14 | NFL | 1 |
| 2021-09-14 02:15:0014.09.2021 |   Las Vegas Raiders vs Baltimore Ravens | 33 – 27 | NFL | 1 |
| 2021-09-16 02:20:0016.09.2021 | Washington Football Team vs New York Giants | 30 – 29 | NFL | 2 |
| 2021-09-18 15:00:0018.09.2021 | Zurich Renegades vs Geneva Seahawks | 7 – 10 | NLA | 10 |
| 2021-09-18 15:00:0018.09.2021 | Basel Gladiators vs Calanda Broncos | 44 – 0 | U16 | 6 |
| 2021-09-18 15:00:0018.09.2021 | Zurich Renegades vs Winterthur Warriors | 34 – 12 | U16 | 6 |
| 2021-09-18 15:00:0018.09.2021 | Schaffhausen Sharks vs Neuchâtel Knights | 15:00:00Verschoben | NLC | 9 |
| 2021-09-18 18:00:0018.09.2021 | Argovia Pirates vs St. Gallen Bears | 9 – 29 | NLB | 6 |
| 2021-09-18 18:00:0018.09.2021 | Glarus Orks vs LUCAF Owls | 21 – 32 | NLC | 9 |
| 2021-09-18 18:00:2418.09.2021 | U19 Wild Card: Tigers vs Grizzlies | 20 – 40 | U19 Elite | – |
| 2021-09-18 18:00:5318.09.2021 | U19 Wild Card: Gladiators vs Warriors | 35 – 21 | U19 Elite | – |
| 2021-09-19 11:00:0019.09.2021 | Lugano Rebels vs Luzern Lions | 11:00:0011:00 | U19 Challenge League | 8 |
| 2021-09-19 12:00:0019.09.2021 | Geneva Seahawks vs Bern Grizzlies | 12:00:0012:00 | U16 | 6 |
| 2021-09-19 14:00:0019.09.2021 | Geneva Whoppers vs Thun Tigers | 7 – 55 | NLB | 6 |
| 2021-09-19 14:00:0019.09.2021 | Lugano Rebels vs Luzern Lions | 14:00:00Verschoben | NLB | 6 |
| 2021-09-19 14:00:0019.09.2021 | Emmen Dragons vs Solothurn Ducks | 42 – 6 | NLC | 9 |
| 2021-09-19 14:00:0019.09.2021 | Fribourg Cardinals vs Bienna Jets | 20 – 22 | NLB | – |
| 2021-09-19 14:00:4919.09.2021 | Spartans vs Invaders | 24 – 33 | NLC | – |
| 2021-09-19 19:00:0019.09.2021 | Carolina Panthers vs New Orleans Saints | 26 – 7 | NFL | 2 |
| 2021-09-19 19:00:0019.09.2021 | Chicago Bears vs Cincinnati Bengals | 20 – 17 | NFL | 2 |
| 2021-09-19 19:00:0019.09.2021 | Cleveland Browns vs Houston Texans | 31 – 21 | NFL | 2 |
| 2021-09-19 19:00:0019.09.2021 | Indianapolis Colts vs Los Angeles Rams | 24 – 27 | NFL | 2 |
| 2021-09-19 19:00:0019.09.2021 | Jacksonville Jaguars vs Denver Broncos | 13 – 23 | NFL | 2 |
| 2021-09-19 19:00:0019.09.2021 | Miami Dolphins vs Buffalo Bills | 0 – 35 | NFL | 2 |
| 2021-09-19 19:00:0019.09.2021 | New York Jets vs New England Patriots | 6 – 25 | NFL | 2 |
| 2021-09-19 19:00:0019.09.2021 | Philadelphia Eagles vs San Francisco 49ers | 11 – 17 | NFL | 2 |
| 2021-09-19 19:00:0019.09.2021 | Pittsburgh Steelers vs Las Vegas Raiders | 17 – 26 | NFL | 2 |
| 2021-09-19 22:05:0019.09.2021 | Arizona Cardinals vs Minnesota Vikings | 33 – 34 | NFL | 2 |
| 2021-09-19 22:05:0019.09.2021 | Tampa Bay Buccaneers vs Atlanta Falcons | 48 – 25 | NFL | 2 |
| 2021-09-19 22:25:0019.09.2021 | Los Angeles Chargers vs Dallas Cowboys | 17 – 20 | NFL | 2 |
| 2021-09-19 22:25:0019.09.2021 | Seattle Seahawks vs Tennessee Titans | 30 – 33 | NFL | 2 |
| 2021-09-20 02:20:0020.09.2021 | Baltimore Ravens vs Kansas City Chiefs | 36 – 35 | NFL | 2 |
| 2021-09-21 02:15:0021.09.2021 | Green Bay Packers vs Detroit Lions | 35 – 17 | NFL | 2 |
| 2021-09-23 02:20:0023.09.2021 | Houston Texans vs Carolina Panthers | 02:20:002:20 | NFL | 3 |
| 2021-09-25 11:00:3625.09.2021 | U19 Semifinal: Zurich Renegades vs Basel Gladiators | 11:00:36TBD | U19 Elite | – |
| 2021-09-25 15:00:5525.09.2021 | U19 Semifinal: Calanda Broncos vs Bern Grizzlies | 15:00:5515:00 | U19 Elite | – |
| 2021-09-25 18:00:0025.09.2021 | Langenthal Invaders vs Schaffhausen Sharks | 18:00:0018:00 | NLC | 10 |
| 2021-09-25 18:00:0025.09.2021 | Zofingen Cheetahs vs Emmen Dragons | 18:00:0018:00 | NLC | 10 |
| 2021-09-25 18:00:0025.09.2021 | Zurich State Spartans vs Glarus Orks | 18:00:0018:00 | NLC | 10 |
| 2021-09-25 18:00:3225.09.2021 | Semifinal: Calanda Broncos vs Winterthur Warriors | 18:00:3218:00 | NLA | – |
| 2021-09-26 02:20:0026.09.2021 | San Francisco 49ers vs Green Bay Packers | 02:20:002:20 | NFL | 3 |
| 2021-09-26 11:00:0026.09.2021 | Luzern Lions vs Riviera Saints | 11:00:0011:00 | U19 Challenge League | 9 |
| 2021-09-26 12:00:0026.09.2021 | Geneva Seahawks vs Thun Tigers | 12:00:0012:00 | U16 | 7 |
| 2021-09-26 12:00:0026.09.2021 | Calanda Broncos vs Zurich Renegades | 12:00:0012:00 | U16 | 7 |
| 2021-09-26 14:00:0026.09.2021 | Geneva Whoppers vs Bienna Jets | 14:00:0014:00 | NLB | 7 |
| 2021-09-26 14:00:0026.09.2021 | Luzern Lions vs Argovia Pirates | 14:00:0014:00 | NLB | 7 |
| 2021-09-26 14:00:0026.09.2021 | Lugano Rebels vs St. Gallen Bears | 14:00:0014:00 | NLB | 7 |
| 2021-09-26 14:00:0026.09.2021 | Solothurn Ducks vs LUCAF Owls | 14:00:0014:00 | NLC | 10 |
| 2021-09-26 14:00:0026.09.2021 | Thun Tigers vs Fribourg Cardinals | 14:00:0014:00 | NLB | – |
| 2021-09-26 14:00:5726.09.2021 | Semifinal: Bern Grizzlies vs Geneva Seahawks | 14:00:5714:00 | NLA | – |
| 2021-09-26 19:00:0026.09.2021 | Buffalo Bills vs Washington Football Team | 19:00:0019:00 | NFL | 3 |
| 2021-09-26 19:00:0026.09.2021 | Cleveland Browns vs Chicago Bears | 19:00:0019:00 | NFL | 3 |
| 2021-09-26 19:00:0026.09.2021 | Detroit Lions vs Baltimore Ravens | 19:00:0019:00 | NFL | 3 |
| 2021-09-26 19:00:0026.09.2021 | Jacksonville Jaguars vs Arizona Cardinals | 19:00:0019:00 | NFL | 3 |
| 2021-09-26 19:00:0026.09.2021 | Kansas City Chiefs vs Los Angeles Chargers | 19:00:0019:00 | NFL | 3 |
| 2021-09-26 19:00:0026.09.2021 | New England Patriots vs New Orleans Saints | 19:00:0019:00 | NFL | 3 |
| 2021-09-26 19:00:0026.09.2021 | New York Giants vs Atlanta Falcons | 19:00:0019:00 | NFL | 3 |
| 2021-09-26 19:00:0026.09.2021 | Pittsburgh Steelers vs Cincinnati Bengals | 19:00:0019:00 | NFL | 3 |
| 2021-09-26 19:00:0026.09.2021 | Tennessee Titans vs Indianapolis Colts | 19:00:0019:00 | NFL | 3 |
| 2021-09-26 22:05:0026.09.2021 | Denver Broncos vs New York Jets | 22:05:0022:05 | NFL | 3 |
| 2021-09-26 22:05:0026.09.2021 | Las Vegas Raiders vs Miami Dolphins | 22:05:0022:05 | NFL | 3 |
| 2021-09-26 22:25:0026.09.2021 | Los Angeles Rams vs Tampa Bay Buccaneers | 22:25:0022:25 | NFL | 3 |
| 2021-09-26 22:25:0026.09.2021 | Minnesota Vikings vs Seattle Seahawks | 22:25:0022:25 | NFL | 3 |
| 2021-09-27 02:15:0027.09.2021 | Dallas Cowboys vs Philadelphia Eagles | 02:15:002:15 | NFL | 3 |
| 2021-09-30 02:20:0030.09.2021 | Cincinnati Bengals vs Jacksonville Jaguars | 02:20:002:20 | NFL | 4 |
| 2021-10-02 14:00:3402.10.2021 | Juniorbowl | 14:00:3414:00 | U19 Elite | – |
| 2021-10-02 18:00:0902.10.2021 | Swissbowl XXXV: Calanda/Warriors vs Grizzlies/Seahawks | 18:00:0918:00 | NLA | – |
| 2021-10-03 02:20:0003.10.2021 | New England Patriots vs Tampa Bay Buccaneers | 02:20:002:20 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | Atlanta Falcons vs Washington Football Team | 19:00:0019:00 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | Buffalo Bills vs Houston Texans | 19:00:0019:00 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | Chicago Bears vs Detroit Lions | 19:00:0019:00 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | Dallas Cowboys vs Carolina Panthers | 19:00:0019:00 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | Miami Dolphins vs Indianapolis Colts | 19:00:0019:00 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | Minnesota Vikings vs Cleveland Browns | 19:00:0019:00 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | New Orleans Saints vs New York Giants | 19:00:0019:00 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | New York Jets vs Tennessee Titans | 19:00:0019:00 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | Philadelphia Eagles vs Kansas City Chiefs | 19:00:0019:00 | NFL | 4 |
| 2021-10-03 22:05:0003.10.2021 | Los Angeles Rams vs Arizona Cardinals | 22:05:0022:05 | NFL | 4 |
| 2021-10-03 22:05:0003.10.2021 | San Francisco 49ers vs Seattle Seahawks | 22:05:0022:05 | NFL | 4 |
| 2021-10-03 22:25:0003.10.2021 | Denver Broncos vs Baltimore Ravens | 22:25:0022:25 | NFL | 4 |
| 2021-10-03 22:25:0003.10.2021 | Green Bay Packers vs Pittsburgh Steelers | 22:25:0022:25 | NFL | 4 |
| 2021-10-04 02:15:0004.10.2021 | Los Angeles Chargers vs Las Vegas Raiders | 02:15:002:15 | NFL | 4 |
| 2021-10-07 02:20:0007.10.2021 | Seattle Seahawks vs Los Angeles Rams | 02:20:002:20 | NFL | 5 |
| 2021-10-09 12:00:0009.10.2021 | Calanda Broncos vs Basel Gladiators | 12:00:0012:00 | U16 | 9 |
| 2021-10-10 02:20:0010.10.2021 | Kansas City Chiefs vs Buffalo Bills | 02:20:002:20 | NFL | 5 |
| 2021-10-10 11:00:0010.10.2021 | Bern Grizzlies vs Thun Tigers | 11:00:0011:00 | U16 | 9 |
| 2021-10-10 11:00:0010.10.2021 | Winterthur Warriors vs Zurich Renegades | 11:00:0011:00 | U16 | 9 |
| 2021-10-10 15:30:0010.10.2021 | Atlanta Falcons vs New York Jets | 15:30:0015:30 | NFL | 5 |
| 2021-10-10 19:00:0010.10.2021 | Carolina Panthers vs Philadelphia Eagles | 19:00:0019:00 | NFL | 5 |
| 2021-10-10 19:00:0010.10.2021 | Cincinnati Bengals vs Green Bay Packers | 19:00:0019:00 | NFL | 5 |
| 2021-10-10 19:00:0010.10.2021 | Houston Texans vs New England Patriots | 19:00:0019:00 | NFL | 5 |
| 2021-10-10 19:00:0010.10.2021 | Jacksonville Jaguars vs Tennessee Titans | 19:00:0019:00 | NFL | 5 |
| 2021-10-10 19:00:0010.10.2021 | Minnesota Vikings vs Detroit Lions | 19:00:0019:00 | NFL | 5 |
| 2021-10-10 19:00:0010.10.2021 | Pittsburgh Steelers vs Denver Broncos | 19:00:0019:00 | NFL | 5 |
| 2021-10-10 19:00:0010.10.2021 | Tampa Bay Buccaneers vs Miami Dolphins | 19:00:0019:00 | NFL | 5 |
| 2021-10-10 19:00:0010.10.2021 | Washington Football Team vs New Orleans Saints | 19:00:0019:00 | NFL | 5 |
| 2021-10-10 22:05:0010.10.2021 | Los Angeles Chargers vs Cleveland Browns | 22:05:0022:05 | NFL | 5 |
| 2021-10-10 22:05:0010.10.2021 | Las Vegas Raiders vs Chicago Bears | 22:05:0022:05 | NFL | 5 |
| 2021-10-10 22:25:0010.10.2021 | Arizona Cardinals vs San Francisco 49ers | 22:25:0022:25 | NFL | 5 |
| 2021-10-10 22:25:0010.10.2021 | Dallas Cowboys vs New York Giants | 22:25:0022:25 | NFL | 5 |
| 2021-10-11 02:15:0011.10.2021 | Baltimore Ravens vs Indianapolis Colts | 02:15:002:15 | NFL | 5 |
| 2021-10-14 02:20:0014.10.2021 | Philadelphia Eagles vs Tampa Bay Buccaneers | 02:20:002:20 | NFL | 6 |
| 2021-10-17 02:20:0017.10.2021 | Pittsburgh Steelers vs Seattle Seahawks | 02:20:002:20 | NFL | 6 |
| 2021-10-17 15:30:0017.10.2021 | Jacksonville Jaguars vs Miami Dolphins | 15:30:0015:30 | NFL | 6 |
| 2021-10-17 19:00:0017.10.2021 | Baltimore Ravens vs Los Angeles Chargers | 19:00:0019:00 | NFL | 6 |
| 2021-10-17 19:00:0017.10.2021 | Carolina Panthers vs Minnesota Vikings | 19:00:0019:00 | NFL | 6 |
| 2021-10-17 19:00:0017.10.2021 | Chicago Bears vs Green Bay Packers | 19:00:0019:00 | NFL | 6 |
| 2021-10-17 19:00:0017.10.2021 | Detroit Lions vs Cincinnati Bengals | 19:00:0019:00 | NFL | 6 |
| 2021-10-17 19:00:0017.10.2021 | Indianapolis Colts vs Houston Texans | 19:00:0019:00 | NFL | 6 |
| 2021-10-17 19:00:0017.10.2021 | New York Giants vs Los Angeles Rams | 19:00:0019:00 | NFL | 6 |
| 2021-10-17 19:00:0017.10.2021 | Washington Football Team vs Kansas City Chiefs | 19:00:0019:00 | NFL | 6 |
| 2021-10-17 22:05:0017.10.2021 | Cleveland Browns vs Arizona Cardinals | 22:05:0022:05 | NFL | 6 |
| 2021-10-17 22:25:0017.10.2021 | Denver Broncos vs Las Vegas Raiders | 22:25:0022:25 | NFL | 6 |
| 2021-10-17 22:25:0017.10.2021 | New England Patriots vs Dallas Cowboys | 22:25:0022:25 | NFL | 6 |
| 2021-10-18 02:15:0018.10.2021 | Tennessee Titans vs Buffalo Bills | 02:15:002:15 | NFL | 6 |
| 2021-10-21 02:20:0021.10.2021 | Cleveland Browns vs Denver Broncos | 02:20:002:20 | NFL | 7 |
| 2021-10-24 02:20:0024.10.2021 | San Francisco 49ers vs Indianapolis Colts | 02:20:002:20 | NFL | 7 |
| 2021-10-24 19:00:0024.10.2021 | Baltimore Ravens vs Cincinnati Bengals | 19:00:0019:00 | NFL | 7 |
| 2021-10-24 19:00:0024.10.2021 | Green Bay Packers vs Washington Football Team | 19:00:0019:00 | NFL | 7 |
| 2021-10-24 19:00:0024.10.2021 | Miami Dolphins vs Atlanta Falcons | 19:00:0019:00 | NFL | 7 |
| 2021-10-24 19:00:0024.10.2021 | New England Patriots vs New York Jets | 19:00:0019:00 | NFL | 7 |
| 2021-10-24 19:00:0024.10.2021 | |
