| 2021-05-15 16:00:0015.05.2021 | Vienna Vikings vs Kragujevac Wild Boars | 82 – 7 | CEFL | – |
| 2021-05-15 18:00:0015.05.2021 | Swarco Raiders vs MIlan Seamen | 41 – 14 | CEFL | – |
| 2021-05-22 00:00:0022.05.2021 | Schwäbisch Hall Unicorns vs Carlstad Crusaders | 00:00:00Abgesagt | CEFL | – |
| 2021-05-29 15:00:0029.05.2021 | Bern Grizzlies vs Bienna Jets | 42 – 43 | U19 Elite | 1 |
| 2021-05-29 16:00:0029.05.2021 | SWARCO Raiders vs Vikings | 20 – 13 | CEFL | – |
| 2021-05-29 18:00:0029.05.2021 | Calanda Broncos vs St. Gallen Bears | 21 – 20 | U19 Elite | 1 |
| 2021-05-29 18:00:0029.05.2021 | Calanda Broncos vs Fehervar Enthroners | 18:00:00Abgesagt | CEFL | – |
| 2021-05-30 11:00:0030.05.2021 | Gladiators vs Tigers | 35 – 20 | U19 Elite | 1 |
| 2021-06-05 14:00:5305.06.2021 | Saarland Hurricanes Juniors vs Gladiators U19 | 0 – 34 | Friendly | – |
| 2021-06-05 15:00:0005.06.2021 | Winterthur Warriors vs Thun Tigers | 7 – 14 | U19 Elite | 2 |
| 2021-06-06 11:00:0006.06.2021 | Zurich Renegades vs Bern Grizzlies | 35 – 20 | U19 Elite | 2 |
| 2021-06-06 12:00:0006.06.2021 | Geneva Seahawks vs St. Gallen Bears | 46 – 14 | U19 Elite | 2 |
| 2021-06-13 11:00:0013.06.2021 | Zurich Renegades vs St. Gallen Bears | 32 – 3 | U19 Elite | 3 |
| 2021-06-13 14:00:0013.06.2021 | Bienna Jets vs Winterthur Warriors | 6 – 32 | U19 Elite | 3 |
| 2021-06-13 14:00:0013.06.2021 | Thun Tigers vs Geneva Seahawks | 19 – 14 | U19 Elite | 3 |
| 2021-06-13 15:00:0013.06.2021 | Calanda Broncos vs Schwäbisch Hall Unicorns | 21 – 35 | CEFL | – |
| 2021-06-19 18:00:0019.06.2021 | Wroclaw Panthers vs Cologne Centurions | 55 – 39 | ELF, North, South | 1 |
| 2021-06-19 18:00:0019.06.2021 | Winterthur Warriors vs Zurich Renegades | 32 – 0 | NLA | 4 |
| 2021-06-19 19:00:0019.06.2021 | Barcelona Dragons vs Stuttgart Surge | 17 – 21 | ELF, North, South | 1 |
| 2021-06-20 11:00:0020.06.2021 | Basel Gladiators vs Winterthur Warriors | 28 – 8 | U19 Elite | 4 |
| 2021-06-20 11:00:0020.06.2021 | Calanda Broncos vs Bienna Jets | 42 – 20 | U19 Elite | 4 |
| 2021-06-20 11:00:0020.06.2021 | St. Gallen Bears vs Bern Grizzlies | 28 – 44 | U19 Elite | 4 |
| 2021-06-20 14:00:0020.06.2021 | Thun Tigers vs Zurich Renegades | 14 – 23 | U19 Elite | 4 |
| 2021-06-20 14:00:0020.06.2021 | Basel Gladiators vs Bern Grizzlies | 22 – 24 | NLA | 4 |
| 2021-06-20 14:00:0020.06.2021 | Calanda Broncos vs Geneva Seahawks | 31 – 0 | NLA | 4 |
| 2021-06-20 15:00:0020.06.2021 | Hamburg Sea Devils vs Frankfurt Galaxy | 17 – 15 | ELF, North, South | 1 |
| 2021-06-20 15:00:0020.06.2021 | Berlin Thunder vs Leipzig Kings | 27 – 37 | ELF, North, South | 1 |
| 2021-06-26 15:00:0026.06.2021 | CEFL Bowl XV: Swarco Raiders vs. Schwäbisch Hall | 16 – 22 | CEFL | – |
| 2021-06-26 18:00:0026.06.2021 | Wroclaw Panthers vs Leipzig Kings | 54 – 28 | ELF, North, South | 2 |
| 2021-06-26 18:00:0026.06.2021 | Winterthur Warriors vs Calanda Broncos | 6 – 31 | NLA | 5 |
| 2021-06-27 14:00:0027.06.2021 | Zurich Renegades vs Basel Gladiators | 19 – 21 | NLA | 5 |
| 2021-06-27 15:00:0027.06.2021 | Cologne Centurions vs Barcelona Dragons | 40 – 12 | ELF, North, South | 2 |
| 2021-06-27 15:00:0027.06.2021 | Stuttgart Surge vs Frankfurt Galaxy | 20 – 42 | ELF, North, South | 2 |
| 2021-06-27 15:00:4727.06.2021 | U19 Friendly: Freiburg Sacristans vs Basel Gladiators | 6 – 17 | Friendly | – |
| 2021-07-03 15:00:0003.07.2021 | Bern Grizzlies vs Basel Gladiators | 20 – 13 | U19 Elite | 6 |
| 2021-07-03 15:00:0003.07.2021 | Calanda Broncos vs Zurich Renegades | 30 – 7 | U19 Elite | 6 |
| 2021-07-03 18:00:0003.07.2021 | Bern Grizzlies vs Basel Gladiators | 55 – 21 | NLA | 6 |
| 2021-07-03 18:00:0003.07.2021 | Calanda Broncos vs Zurich Renegades | 46 – 0 | NLA | 6 |
| 2021-07-03 19:00:0003.07.2021 | Barcelona Dragons vs Hamburg Sea Devils | 14 – 32 | ELF, North, South | 3 |
| 2021-07-04 11:00:0004.07.2021 | Geneva Seahawks vs Bienna Jets | 34 – 21 | U19 Elite | 6 |
| 2021-07-04 11:00:0004.07.2021 | Thun Tigers vs St. Gallen Bears | 28 – 3 | U19 Elite | 6 |
| 2021-07-04 15:00:0004.07.2021 | Leipzig Kings vs Cologne Centurions | 47 – 48 | ELF, North, South | 3 |
| 2021-07-04 15:00:0004.07.2021 | Frankfurt Galaxy vs Wroclaw Panthers | 22 – 13 | ELF, North, South | 3 |
| 2021-07-04 15:00:0004.07.2021 | Berlin Thunder vs Stuttgart Surge | 40 – 19 | ELF, North, South | 3 |
| 2021-07-04 15:00:0004.07.2021 | Geneva Seahawks vs Winterthur Warriors | 35 – 6 | NLA | 6 |
| 2021-07-10 15:00:0010.07.2021 | Bienna Jets vs Thun Tigers | 21 – 26 | U19 Elite | 7 |
| 2021-07-11 11:00:0011.07.2021 | Bern Grizzlies vs Calanda Broncos | 8 – 41 | U19 Elite | 7 |
| 2021-07-11 11:00:0011.07.2021 | Geneva Seahawks vs Basel Gladiators | 22 – 27 | U19 Elite | 7 |
| 2021-07-11 11:00:0011.07.2021 | Zurich Renegades vs Winterthur Warriors | 23 – 0 | U19 Elite | 7 |
| 2021-07-11 14:00:0011.07.2021 | Bern Grizzlies vs Calanda Broncos | 26 – 21 | NLA | 7 |
| 2021-07-11 14:00:0011.07.2021 | Geneva Seahawks vs Basel Gladiators | 69 – 21 | NLA | 7 |
| 2021-07-11 14:00:0011.07.2021 | Zurich Renegades vs Winterthur Warriors | 10 – 35 | NLA | 7 |
| 2021-07-11 15:00:0011.07.2021 | Cologne Centurions vs Frankfurt Galaxy | 20 – 41 | ELF, North, South | 4 |
| 2021-07-11 15:00:0011.07.2021 | Stuttgart Surge vs Leipzig Kings | 27 – 24 | ELF, North, South | 4 |
| 2021-07-11 18:00:0011.07.2021 | Hamburg Sea Devils vs Berlin Thunder | 44 – 6 | ELF, North, South | 4 |
| 2021-07-17 15:00:0017.07.2021 | Basel Gladiators vs Calanda Broncos | 7 – 16 | U19 Elite | 8 |
| 2021-07-17 15:00:0017.07.2021 | Winterthur Warriors vs Geneva Seahawks | 32 – 6 | U19 Elite | 8 |
| 2021-07-17 15:00:0017.07.2021 | Frankfurt Galaxy vs Barcelona Dragons | 42 – 22 | ELF, North, South | 5 |
| 2021-07-17 18:00:0017.07.2021 | Basel Gladiators vs Calanda Broncos | 22 – 48 | NLA | 8 |
| 2021-07-17 18:00:0017.07.2021 | Winterthur Warriors vs Geneva Seahawks | 17 – 33 | NLA | 8 |
| 2021-07-18 14:00:0018.07.2021 | Zurich Renegades vs Bern Grizzlies | 0 – 49 | NLA | 8 |
| 2021-07-18 15:00:0018.07.2021 | Berlin Thunder vs Wroclaw Panthers | 26 – 45 | ELF, North, South | 5 |
| 2021-07-18 15:00:0018.07.2021 | Leipzig Kings vs Hamburg Sea Devils | 0 – 55 | ELF, North, South | 5 |
| 2021-07-24 15:00:0024.07.2021 | Wroclaw Panthers vs Hamburg Sea Devils | 23 – 26 | ELF, North, South | 6 |
| 2021-07-24 18:00:0024.07.2021 | Glarus Orks vs Zofingen Cheetahs | 57 – 0 | NLC | 1 |
| 2021-07-24 18:00:0024.07.2021 | Langenthal Invaders vs Zurich State Spartans | 41 – 0 | NLC | 1 |
| 2021-07-24 19:00:0024.07.2021 | Barcelona Dragons vs Berlin Thunder | 41 – 16 | ELF, North, South | 6 |
| 2021-07-25 14:00:0025.07.2021 | Emmen Dragons vs Schaffhausen Sharks | 6 – 14 | NLC | 1 |
| 2021-07-25 14:00:0025.07.2021 | Solothurn Ducks vs Morges Bandits | 0 – 28 | NLC | 1 |
| 2021-07-25 15:00:0025.07.2021 | Stuttgart Surge vs Cologne Centurions | 23 – 39 | ELF, North, South | 6 |
| 2021-07-31 18:00:0031.07.2021 | Hamburg Sea Devils vs Barcelona Dragons | 22 – 17 | ELF, North, South | 7 |
| 2021-07-31 18:00:0031.07.2021 | Solothurn Ducks vs Neuchâtel Knights | 0 – 34 | NLC | 2 |
| 2021-08-01 15:00:0001.08.2021 | Cologne Centurions vs Wroclaw Panthers | 33 – 31 | ELF, North, South | 7 |
| 2021-08-01 15:00:0001.08.2021 | Leipzig Kings vs Berlin Thunder | 37 – 24 | ELF, North, South | 7 |
| 2021-08-01 15:00:0001.08.2021 | Frankfurt Galaxy vs Stuttgart Surge | 57 – 3 | ELF, North, South | 7 |
| 2021-08-07 18:00:0007.08.2021 | Langenthal Invaders vs Morges Bandits | 50 – 20 | NLC | 3 |
| 2021-08-07 19:00:0007.08.2021 | Barcelona Dragons vs Cologne Centurions | 60 – 51 | ELF, North, South | 8 |
| 2021-08-08 15:00:0008.08.2021 | Frankfurt Galaxy vs Hamburg Sea Devils | 35 – 9 | ELF, North, South | 8 |
| 2021-08-08 15:00:0008.08.2021 | Leipzig Kings vs Stuttgart Surge | 49 – 23 | ELF, North, South | 8 |
| 2021-08-14 12:00:0014.08.2021 | Winterthur Warriors vs Calanda Broncos | 8 – 36 | U16 | 1 |
| 2021-08-14 13:00:0014.08.2021 | Berlin Thunder vs Hamburg Sea Devils | 20 – 28 | ELF, North, South | 9 |
| 2021-08-14 15:00:0014.08.2021 | Winterthur Warriors vs Calanda Broncos | 12 – 23 | U19 Elite | 9 |
| 2021-08-14 15:00:0014.08.2021 | Argovia Pirates vs Luzern Lions | 28 – 8 | U19 Challenge League | 3 |
| 2021-08-14 18:00:0014.08.2021 | Argovia Pirates vs Luzern Lions | 18 – 3 | NLB | 1 |
| 2021-08-15 11:00:0015.08.2021 | Bienna Jets vs Basel Gladiators | 14 – 46 | U19 Elite | 9 |
| 2021-08-15 11:00:0015.08.2021 | Zurich Renegades vs Basel Gladiators | 48 – 8 | U16 | 1 |
| 2021-08-15 14:00:0015.08.2021 | Bienna Jets vs Geneva Whoppers | 50 – 0 | NLB | 1 |
| 2021-08-15 14:00:0015.08.2021 | Thun Tigers vs Bern Grizzlies | 50 – 12 | U16 | 1 |
| 2021-08-15 14:00:0015.08.2021 | LUCAF Owls vs Emmen Dragons | 29 – 18 | NLC | 4 |
| 2021-08-15 14:00:0015.08.2021 | Morges Bandits vs Glarus Orks | 30 – 16 | NLC | 4 |
| 2021-08-15 14:00:0015.08.2021 | Neuchâtel Knights vs Zurich State Spartans | 7 – 6 | NLC | 4 |
| 2021-08-15 14:00:0015.08.2021 | Solothurn Ducks vs Zofingen Cheetahs | 37 – 0 | NLC | 4 |
| 2021-08-15 15:00:0015.08.2021 | Wroclaw Panthers vs Frankfurt Galaxy | 7 – 36 | ELF, North, South | 9 |
| 2021-08-15 15:00:0015.08.2021 | Stuttgart Surge vs Barcelona Dragons | 12 – 30 | ELF, North, South | 9 |
| 2021-08-21 14:00:0021.08.2021 | Lugano Rebels vs Riviera Saints | 0 – 33 | U19 Challenge League | 4 |
| 2021-08-21 18:00:0021.08.2021 | Cologne Centurions vs Leipzig Kings | 24 – 42 | ELF, North, South | 10 |
| 2021-08-21 18:00:0021.08.2021 | Lugano Rebels vs Argovia Pirates | 6 – 25 | NLB | 2 |
| 2021-08-21 18:00:0021.08.2021 | Calanda Broncos vs Bern Grizzlies | 35 – 10 | NLA | 10 |
| 2021-08-21 18:00:0021.08.2021 | Zofingen Cheetahs vs Langenthal Invaders | 0 – 70 | NLC | 2 |
| 2021-08-22 11:00:0022.08.2021 | Thun Tigers vs Bern Grizzlies | 41 – 14 | U19 Elite | 10 |
| 2021-08-22 11:00:0022.08.2021 | Basel Gladiators vs Winterthur Warriors | 37 – 16 | U16 | 2 |
| 2021-08-22 11:00:0022.08.2021 | Zurich Renegades vs Calanda Broncos | 12 – 20 | U16 | 2 |
| 2021-08-22 14:00:0022.08.2021 | Zurich Renegades vs Geneva Seahawks | 6 – 0 | U19 Elite | 10 |
| 2021-08-22 14:00:0022.08.2021 | Basel Gladiators vs Winterthur Warriors | 13 – 46 | NLA | 10 |
| 2021-08-22 14:00:0022.08.2021 | Schaffhausen Sharks vs Zurich State Spartans | 25 – 0 | NLC | 5 |
| 2021-08-22 14:00:0022.08.2021 | Geneva Whoppers vs Fribourg Cardinals | 6 – 2 | NLB | – |
| 2021-08-22 14:00:0522.08.2021 | Luzern Lions vs St. Gallen Bears | 6 – 13 | NLB | 2 |
| 2021-08-22 15:00:0022.08.2021 | Hamburg Sea Devils vs Wroclaw Panthers | 24 – 30 | ELF, North, South | 10 |
| 2021-08-22 15:00:0022.08.2021 | Berlin Thunder vs Barcelona Dragons | 19 – 3 | ELF, North, South | 10 |
| 2021-08-22 16:00:0022.08.2021 | Thun Tigers vs Bienna Jets | 28 – 19 | NLB | 2 |
| 2021-08-28 12:00:0028.08.2021 | Winterthur Warriors vs Basel Gladiators | 22 – 20 | U16 | 3 |
| 2021-08-28 15:00:0028.08.2021 | Winterthur Warriors vs Bern Grizzlies | 18 – 46 | U19 Elite | 11 |
| 2021-08-28 18:00:0028.08.2021 | Winterthur Warriors vs Bern Grizzlies | 0 – 17 | NLA | 11 |
| 2021-08-28 18:00:0028.08.2021 | Emmen Dragons vs Zurich State Spartans | 36 – 13 | NLC | 6 |
| 2021-08-28 18:00:0028.08.2021 | Glarus Orks vs Langenthal Invaders | 13 – 48 | NLC | 6 |
| 2021-08-28 18:00:0028.08.2021 | Zofingen Cheetahs vs Schaffhausen Sharks | 0 – 63 | NLC | 6 |
| 2021-08-28 19:00:0028.08.2021 | Barcelona Dragons vs Frankfurt Galaxy | 14 – 22 | ELF, North, South | 11 |
| 2021-08-28 20:00:0028.08.2021 | Wroclaw Panthers vs Berlin Thunder | 35 – 12 | ELF, North, South | 11 |
| 2021-08-29 11:00:0029.08.2021 | Bienna Jets vs Zurich Renegades | 0 – 50 | U19 Elite | 11 |
| 2021-08-29 11:00:0029.08.2021 | St. Gallen Bears vs Basel Gladiators | 0 – 49 | U19 Elite | 11 |
| 2021-08-29 11:00:0029.08.2021 | Thun Tigers vs Geneva Seahawks | 36 – 22 | U16 | 3 |
| 2021-08-29 12:00:0029.08.2021 | Geneva Seahawks vs Calanda Broncos | 8 – 27 | U19 Elite | 11 |
| 2021-08-29 14:00:0029.08.2021 | Luzern Lions vs Lugano Rebels | 41 – 14 | NLB | 3 |
| 2021-08-29 14:00:0029.08.2021 | St. Gallen Bears vs Argovia Pirates | 18 – 0 | NLB | 3 |
| 2021-08-29 14:00:0029.08.2021 | Thun Tigers vs Geneva Whoppers | 49 – 0 | NLB | 3 |
| 2021-08-29 14:00:0029.08.2021 | Neuchâtel Knights vs LUCAF Owls | 3 – 34 | NLC | 6 |
| 2021-08-29 14:00:0029.08.2021 | Bienna Jets vs Fribourg Cardinals | 19 – 0 | NLB | – |
| 2021-08-29 15:00:0029.08.2021 | Hamburg Sea Devils vs Leipzig Kings | 17 – 18 | ELF, North, South | 11 |
| 2021-08-29 15:00:0029.08.2021 | Geneva Seahawks vs Calanda Broncos | 28 – 35 | NLA | 11 |
| 2021-08-29 17:00:0029.08.2021 | Cologne Centurions vs Stuttgart Surge | 19 – 9 | ELF, North, South | 11 |
| 2021-09-02 14:00:5002.09.2021 | Juniorbowl 2021: Calanda Broncos vs Basel Gladiators | 14:00:5014:00 | U19 Elite | – |
| 2021-09-04 11:00:0004.09.2021 | Bern Grizzlies vs Geneva Seahawks | 11:00:0011:00 | U16 | 4 |
| 2021-09-04 11:00:0004.09.2021 | Basel Gladiators vs Zurich Renegades | 0 – 54 | U16 | 4 |
| 2021-09-04 12:00:0004.09.2021 | Calanda Broncos vs Winterthur Warriors | 32 – 12 | U16 | 4 |
| 2021-09-04 15:00:0004.09.2021 | Calanda Broncos vs Thun Tigers | 30 – 25 | U19 Elite | 12 |
| 2021-09-04 15:00:0004.09.2021 | Riviera Saints vs Argovia Pirates | 13 – 37 | U19 Challenge League | 6 |
| 2021-09-04 18:00:0004.09.2021 | Emmen Dragons vs Langenthal Invaders | 20 – 28 | NLC | 7 |
| 2021-09-04 18:00:0004.09.2021 | Morges Bandits vs Neuchâtel Knights | 22 – 19 | NLC | 7 |
| 2021-09-04 18:00:0004.09.2021 | Zurich State Spartans vs Zofingen Cheetahs | 49 – 0 | NLC | 7 |
| 2021-09-05 11:00:0005.09.2021 | Bern Grizzlies vs Geneva Seahawks | 40 – 38 | U19 Elite | 12 |
| 2021-09-05 11:00:0005.09.2021 | Basel Gladiators vs Zurich Renegades | 21 – 32 | U19 Elite | 12 |
| 2021-09-05 11:00:0005.09.2021 | St. Gallen Bears vs Winterthur Warriors | 14 – 27 | U19 Elite | 12 |
| 2021-09-05 14:00:0005.09.2021 | St. Gallen Bears vs Lugano Rebels | 11 – 0 | NLB | 4 |
| 2021-09-05 14:00:0005.09.2021 | Basel Gladiators vs Zurich Renegades | 28 – 7 | NLA | 12 |
| 2021-09-05 14:00:0005.09.2021 | Bern Grizzlies vs Geneva Seahawks | 24 – 14 | NLA | 12 |
| 2021-09-05 14:00:0005.09.2021 | Schaffhausen Sharks vs Glarus Orks | 28 – 3 | NLC | 7 |
| 2021-09-05 14:00:0005.09.2021 | Fribourg Cardinals vs Thun Tigers | 0 – 55 | NLB | – |
| 2021-09-05 15:00:0005.09.2021 | Stuttgart Surge vs Berlin Thunder | 0 – 38 | ELF, North, South | 12 |
| 2021-09-05 15:00:0005.09.2021 | Leipzig Kings vs Wroclaw Panthers | 13 – 21 | ELF, North, South | 12 |
| 2021-09-05 15:00:0005.09.2021 | Frankfurt Galaxy vs Cologne Centurions | 45 – 7 | ELF, North, South | 12 |
| 2021-09-09 02:20:0009.09.2021 | Tampa Bay Buccaneers vs Dallas Cowboys | 31 – 29 | NFL | 1 |
| 2021-09-11 14:45:4411.09.2021 | Frankfurt Galaxy vs Cologne Centurions | 36 – 6 | ELF | – |
| 2021-09-11 15:00:0011.09.2021 | Argovia Pirates vs Lugano Rebels | 49 – 0 | U19 Challenge League | 7 |
| 2021-09-11 18:00:0011.09.2021 | Argovia Pirates vs Lugano Rebels | 13 – 22 | NLB | 5 |
| 2021-09-11 18:00:0011.09.2021 | Bienna Jets vs Thun Tigers | 6 – 49 | NLB | 5 |
| 2021-09-12 11:00:0012.09.2021 | St. Gallen Bears vs Bienna Jets | 50 – 0 | U19 Elite | 10 |
| 2021-09-12 14:00:0012.09.2021 | St. Gallen Bears vs Luzern Lions | 2 – 6 | NLB | 5 |
| 2021-09-12 14:00:0012.09.2021 | Bern Grizzlies vs Winterthur Warriors | 41 – 3 | NLA | 13 |
| 2021-09-12 14:00:0012.09.2021 | Calanda Broncos vs Basel Gladiators | 52 – 14 | NLA | 13 |
| 2021-09-12 14:00:0012.09.2021 | Zofingen Cheetahs vs Schaffhausen Sharks | 8 – 57 | NLC | 3 |
| 2021-09-12 14:00:0012.09.2021 | Fribourg Cardinals vs Geneva Whoppers | 41 – 8 | NLB | – |
| 2021-09-12 14:45:0112.09.2021 | Hamburg Sea Devils vs Wroclaw Panthers | 30 – 27 | ELF | – |
| 2021-09-12 15:00:0012.09.2021 | Geneva Seahawks vs Zurich Renegades | 57 – 6 | NLA | 13 |
| 2021-09-12 19:00:0012.09.2021 | Atlanta Falcons vs Philadelphia Eagles | 6 – 32 | NFL | 1 |
| 2021-09-12 19:00:0012.09.2021 | Buffalo Bills vs Pittsburgh Steelers | 16 – 23 | NFL | 1 |
| 2021-09-12 19:00:0012.09.2021 | Carolina Panthers vs New York Jets | 19 – 14 | NFL | 1 |
| 2021-09-12 19:00:0012.09.2021 | Cincinnati Bengals vs Minnesota Vikings | 27 – 24 | NFL | 1 |
| 2021-09-12 19:00:0012.09.2021 | Detroit Lions vs San Francisco 49ers | 33 – 41 | NFL | 1 |
| 2021-09-12 19:00:0012.09.2021 | Houston Texans vs Jacksonville Jaguars | 37 – 21 | NFL | 1 |
| 2021-09-12 19:00:0012.09.2021 | Indianapolis Colts vs Seattle Seahawks | 16 – 28 | NFL | 1 |
| 2021-09-12 19:00:0012.09.2021 | Tennessee Titans vs Arizona Cardinals | 13 – 38 | NFL | 1 |
| 2021-09-12 19:00:0012.09.2021 | Washington Football Team vs Los Angeles Chargers | 16 – 20 | NFL | 1 |
| 2021-09-12 22:25:0012.09.2021 | Kansas City Chiefs vs Cleveland Browns | 33 – 29 | NFL | 1 |
| 2021-09-12 22:25:0012.09.2021 | New England Patriots vs Miami Dolphins | 16 – 17 | NFL | 1 |
| 2021-09-12 22:25:0012.09.2021 | New Orleans Saints vs Green Bay Packers | 38 – 3 | NFL | 1 |
| 2021-09-12 22:25:0012.09.2021 | New York Giants vs Denver Broncos | 13 – 27 | NFL | 1 |
| 2021-09-13 02:20:0013.09.2021 | Los Angeles Rams vs Chicago Bears | 34 – 14 | NFL | 1 |
| 2021-09-14 02:15:0014.09.2021 | Las Vegas Raiders vs Baltimore Ravens | 33 – 27 | NFL | 1 |
| 2021-09-16 02:20:0016.09.2021 | Washington Football Team vs New York Giants | 30 – 29 | NFL | 2 |
| 2021-09-18 15:00:0018.09.2021 | Zurich Renegades vs Geneva Seahawks | 7 – 10 | NLA | 10 |
| 2021-09-18 15:00:0018.09.2021 | Basel Gladiators vs Calanda Broncos | 44 – 0 | U16 | 6 |
| 2021-09-18 15:00:0018.09.2021 | Zurich Renegades vs Winterthur Warriors | 34 – 12 | U16 | 6 |
| 2021-09-18 18:00:0018.09.2021 | Argovia Pirates vs St. Gallen Bears | 9 – 29 | NLB | 6 |
| 2021-09-18 18:00:0018.09.2021 | Glarus Orks vs LUCAF Owls | 21 – 32 | NLC | 9 |
| 2021-09-18 18:00:2418.09.2021 | U19 Wild Card: Tigers vs Grizzlies | 20 – 40 | U19 Elite | – |
| 2021-09-18 18:00:5318.09.2021 | U19 Wild Card: Gladiators vs Warriors | 35 – 21 | U19 Elite | – |
| 2021-09-19 11:00:0019.09.2021 | Lugano Rebels vs Luzern Lions | 11:00:0011:00 | U19 Challenge League | 8 |
| 2021-09-19 12:00:0019.09.2021 | Geneva Seahawks vs Bern Grizzlies | 12:00:0012:00 | U16 | 6 |
| 2021-09-19 14:00:0019.09.2021 | Geneva Whoppers vs Thun Tigers | 7 – 55 | NLB | 6 |
| 2021-09-19 14:00:0019.09.2021 | Lugano Rebels vs Luzern Lions | 0 – 0 | NLB | 6 |
| 2021-09-19 14:00:0019.09.2021 | Emmen Dragons vs Solothurn Ducks | 42 – 6 | NLC | 9 |
| 2021-09-19 14:00:0019.09.2021 | Fribourg Cardinals vs Bienna Jets | 20 – 22 | NLB | – |
| 2021-09-19 14:00:4919.09.2021 | Spartans vs Invaders | 24 – 33 | NLC | – |
| 2021-09-19 19:00:0019.09.2021 | Carolina Panthers vs New Orleans Saints | 26 – 7 | NFL | 2 |
| 2021-09-19 19:00:0019.09.2021 | Chicago Bears vs Cincinnati Bengals | 20 – 17 | NFL | 2 |
| 2021-09-19 19:00:0019.09.2021 | Cleveland Browns vs Houston Texans | 31 – 21 | NFL | 2 |
| 2021-09-19 19:00:0019.09.2021 | Indianapolis Colts vs Los Angeles Rams | 24 – 27 | NFL | 2 |
| 2021-09-19 19:00:0019.09.2021 | Jacksonville Jaguars vs Denver Broncos | 13 – 23 | NFL | 2 |
| 2021-09-19 19:00:0019.09.2021 | Miami Dolphins vs Buffalo Bills | 0 – 35 | NFL | 2 |
| 2021-09-19 19:00:0019.09.2021 | New York Jets vs New England Patriots | 6 – 25 | NFL | 2 |
| 2021-09-19 19:00:0019.09.2021 | Philadelphia Eagles vs San Francisco 49ers | 11 – 17 | NFL | 2 |
| 2021-09-19 19:00:0019.09.2021 | Pittsburgh Steelers vs Las Vegas Raiders | 17 – 26 | NFL | 2 |
| 2021-09-19 22:05:0019.09.2021 | Arizona Cardinals vs Minnesota Vikings | 34 – 33 | NFL | 2 |
| 2021-09-19 22:05:0019.09.2021 | Tampa Bay Buccaneers vs Atlanta Falcons | 48 – 25 | NFL | 2 |
| 2021-09-19 22:25:0019.09.2021 | Los Angeles Chargers vs Dallas Cowboys | 17 – 20 | NFL | 2 |
| 2021-09-19 22:25:0019.09.2021 | Seattle Seahawks vs Tennessee Titans | 30 – 33 | NFL | 2 |
| 2021-09-20 02:20:0020.09.2021 | Baltimore Ravens vs Kansas City Chiefs | 36 – 35 | NFL | 2 |
| 2021-09-21 02:15:0021.09.2021 | Green Bay Packers vs Detroit Lions | 35 – 17 | NFL | 2 |
| 2021-09-23 02:20:0023.09.2021 | Houston Texans vs Carolina Panthers | 9 – 24 | NFL | 3 |
| 2021-09-25 05:00:0025.09.2021 | Geneva Seahawks vs Thun Tigers | 18 – 32 | U16 | 7 |
| 2021-09-25 15:00:5525.09.2021 | U19 Semifinal: Calanda Broncos vs Bern Grizzlies | 25 – 8 | U19 Elite | – |
| 2021-09-25 18:00:0025.09.2021 | Langenthal Invaders vs Schaffhausen Sharks | 8 – 29 | NLC | 10 |
| 2021-09-25 18:00:0025.09.2021 | Zurich State Spartans vs Glarus Orks | 55 – 15 | NLC | 10 |
| 2021-09-25 18:00:3225.09.2021 | Semifinal: Calanda Broncos vs Winterthur Warriors | 35 – 8 | NLA | – |
| 2021-09-26 11:00:0026.09.2021 | Luzern Lions vs Riviera Saints | 52 – 0 | U19 Challenge League | 9 |
| 2021-09-26 11:00:3626.09.2021 | U19 Semifinal: Zurich Renegades vs Basel Gladiators | 14 – 24 | U19 Elite | – |
| 2021-09-26 12:00:0026.09.2021 | Calanda Broncos vs Zurich Renegades | 16 – 20 | U16 | 7 |
| 2021-09-26 14:00:0026.09.2021 | Geneva Whoppers vs Bienna Jets | 24 – 60 | NLB | 7 |
| 2021-09-26 14:00:0026.09.2021 | Luzern Lions vs Argovia Pirates | 23 – 15 | NLB | 7 |
| 2021-09-26 14:00:0026.09.2021 | Lugano Rebels vs St. Gallen Bears | 6 – 27 | NLB | 7 |
| 2021-09-26 14:00:0026.09.2021 | Thun Tigers vs Fribourg Cardinals | 56 – 6 | NLB | – |
| 2021-09-26 14:00:5726.09.2021 | Semifinal: Bern Grizzlies vs Geneva Seahawks | 21 – 16 | NLA | – |
| 2021-09-26 15:00:4826.09.2021 | Hamburg Sea Devils vs Frankfurt Galaxy | 30 – 32 | ELF | – |
| 2021-09-26 19:00:0026.09.2021 | Buffalo Bills vs Washington Football Team | 43 – 21 | NFL | 3 |
| 2021-09-26 19:00:0026.09.2021 | Cleveland Browns vs Chicago Bears | 26 – 6 | NFL | 3 |
| 2021-09-26 19:00:0026.09.2021 | Detroit Lions vs Baltimore Ravens | 17 – 19 | NFL | 3 |
| 2021-09-26 19:00:0026.09.2021 | Jacksonville Jaguars vs Arizona Cardinals | 19 – 31 | NFL | 3 |
| 2021-09-26 19:00:0026.09.2021 | Kansas City Chiefs vs Los Angeles Chargers | 24 – 30 | NFL | 3 |
| 2021-09-26 19:00:0026.09.2021 | New England Patriots vs New Orleans Saints | 13 – 28 | NFL | 3 |
| 2021-09-26 19:00:0026.09.2021 | New York Giants vs Atlanta Falcons | 14 – 17 | NFL | 3 |
| 2021-09-26 19:00:0026.09.2021 | Pittsburgh Steelers vs Cincinnati Bengals | 10 – 24 | NFL | 3 |
| 2021-09-26 19:00:0026.09.2021 | Tennessee Titans vs Indianapolis Colts | 25 – 16 | NFL | 3 |
| 2021-09-26 22:05:0026.09.2021 | Denver Broncos vs New York Jets | 26 – 0 | NFL | 3 |
| 2021-09-26 22:05:0026.09.2021 | Las Vegas Raiders vs Miami Dolphins | 31 – 28 | NFL | 3 |
| 2021-09-26 22:25:0026.09.2021 | Los Angeles Rams vs Tampa Bay Buccaneers | 34 – 24 | NFL | 3 |
| 2021-09-26 22:25:0026.09.2021 | Minnesota Vikings vs Seattle Seahawks | 30 – 17 | NFL | 3 |
| 2021-09-27 02:15:0027.09.2021 | Dallas Cowboys vs Philadelphia Eagles | 41 – 21 | NFL | 3 |
| 2021-09-27 02:20:0027.09.2021 | San Francisco 49ers vs Green Bay Packers | 28 – 30 | NFL | 3 |
| 2021-09-30 02:20:0030.09.2021 | Cincinnati Bengals vs Jacksonville Jaguars | 24 – 21 | NFL | 4 |
| 2021-10-02 14:00:3402.10.2021 | Juniorbowl: Calanda Broncos vs Basel Gladiators | 21 – 6 | U19 Elite | – |
| 2021-10-02 18:00:0902.10.2021 | Swissbowl XXXV: Calanda Broncos vs Bern Grizzlies | 21 – 12 | NLA | – |
| 2021-10-03 14:00:0003.10.2021 | Schaffhausen Sharks vs Neuchâtel Knights | 27 – 3 | NLC | 9 |
| 2021-10-03 14:00:0003.10.2021 | Zofingen Cheetahs vs Emmen Dragons | 6 – 63 | NLC | 10 |
| 2021-10-03 14:00:0003.10.2021 | Solothurn Ducks vs LUCAF Owls | 0 – 51 | NLC | 10 |
| 2021-10-03 19:00:0003.10.2021 | Atlanta Falcons vs Washington Football Team | 30 – 34 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | Buffalo Bills vs Houston Texans | 40 – 0 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | Chicago Bears vs Detroit Lions | 24 – 14 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | Dallas Cowboys vs Carolina Panthers | 36 – 28 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | Miami Dolphins vs Indianapolis Colts | 17 – 27 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | Minnesota Vikings vs Cleveland Browns | 7 – 14 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | New Orleans Saints vs New York Giants | 21 – 27 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | New York Jets vs Tennessee Titans | 27 – 24 | NFL | 4 |
| 2021-10-03 19:00:0003.10.2021 | Philadelphia Eagles vs Kansas City Chiefs | 30 – 42 | NFL | 4 |
| 2021-10-03 22:05:0003.10.2021 | Los Angeles Rams vs Arizona Cardinals | 20 – 37 | NFL | 4 |
| 2021-10-03 22:05:0003.10.2021 | San Francisco 49ers vs Seattle Seahawks | 21 – 28 | NFL | 4 |
| 2021-10-03 22:25:0003.10.2021 | Denver Broncos vs Baltimore Ravens | 7 – 23 | NFL | 4 |
| 2021-10-03 22:25:0003.10.2021 | Green Bay Packers vs Pittsburgh Steelers | 27 – 17 | NFL | 4 |
| 2021-10-04 02:20:0004.10.2021 | New England Patriots vs Tampa Bay Buccaneers | 17 – 19 | NFL | 4 |
| 2021-10-05 02:15:0005.10.2021 | Los Angeles Chargers vs Las Vegas Raiders | 28 – 14 | NFL | 4 |
| 2021-10-07 02:20:0007.10.2021 | Seattle Seahawks vs Los Angeles Rams | 17 – 26 | NFL | 5 |
| 2021-10-09 12:00:0009.10.2021 | Calanda Broncos vs Basel Gladiators | 62 – 6 | U16 | 9 |
| 2021-10-09 18:00:1209.10.2021 | 1/4-Final: Thun Tigers vs Lugano Rebels | 56 – 0 | NLB | – |
| 2021-10-09 18:00:2509.10.2021 | 1/4-Final: Luzern Lions vs Argovia Pirates | 34 – 3 | NLB | – |
| 2021-10-10 02:20:0010.10.2021 | Kansas City Chiefs vs Buffalo Bills | 20 – 38 | NFL | 5 |
| 2021-10-10 11:00:0010.10.2021 | Bern Grizzlies vs Thun Tigers | 14 – 32 | U16 | 9 |
| 2021-10-10 14:00:0010.10.2021 | Winterthur Warriors vs Zurich Renegades | 0 – 46 | U16 | 9 |
| 2021-10-10 14:00:0010.10.2021 | Glarus Orks vs Emmen Dragons | 18 – 0 | NLC | 2 |
| 2021-10-10 14:00:0410.10.2021 | 1/4-Final: Bienna Jets vs Argovia Pirates | 20 – 3 | NLB | – |
| 2021-10-10 14:00:3110.10.2021 | 1/4-Final: St. Gallen Bears vs Geneva Whoppers | 50 – 0 | NLB | – |
| 2021-10-10 14:00:4910.10.2021 | Owls vs Bandits | 26 – 11 | NLC | – |
| 2021-10-10 15:30:0010.10.2021 | Atlanta Falcons vs New York Jets | 27 – 20 | NFL | 5 |
| 2021-10-10 19:00:0010.10.2021 | Carolina Panthers vs Philadelphia Eagles | 18 – 21 | NFL | 5 |
| 2021-10-10 19:00:0010.10.2021 | Cincinnati Bengals vs Green Bay Packers | 22 – 25 | NFL | 5 |
| 2021-10-10 19:00:0010.10.2021 | Houston Texans vs New England Patriots | 22 – 25 | NFL | 5 |
| 2021-10-10 19:00:0010.10.2021 | Jacksonville Jaguars vs Tennessee Titans | 19 – 37 | NFL | 5 |
| 2021-10-10 19:00:0010.10.2021 | Minnesota Vikings vs Detroit Lions | 19 – 17 | NFL | 5 |
| 2021-10-10 19:00:0010.10.2021 | Pittsburgh Steelers vs Denver Broncos | 27 – 19 | NFL | 5 |
| 2021-10-10 19:00:0010.10.2021 | Tampa Bay Buccaneers vs Miami Dolphins | 45 – 17 | NFL | 5 |
| 2021-10-10 19:00:0010.10.2021 | Washington Football Team vs New Orleans Saints | 22 – 33 | NFL | 5 |
| 2021-10-10 22:05:0010.10.2021 | Los Angeles Chargers vs Cleveland Browns | 47 – 42 | NFL | 5 |
| 2021-10-10 22:05:0010.10.2021 | Las Vegas Raiders vs Chicago Bears | 9 – 20 | NFL | 5 |
| 2021-10-10 22:25:0010.10.2021 | Arizona Cardinals vs San Francisco 49ers | 17 – 10 | NFL | 5 |
| 2021-10-10 22:25:0010.10.2021 | Dallas Cowboys vs New York Giants | 44 – 20 | NFL | 5 |
| 2021-10-11 02:15:0011.10.2021 | Baltimore Ravens vs Indianapolis Colts | 31 – 25 | NFL | 5 |
| 2021-10-14 02:20:0014.10.2021 | Philadelphia Eagles vs Tampa Bay Buccaneers | 22 – 28 | NFL | 6 |
| 2021-10-16 15:00:3016.10.2021 | 1/2-Finale: Argovia Pirates U19 vs Lugano Rebels U19 | 58 – 6 | U19 Challenge League | – |
| 2021-10-16 15:00:3916.10.2021 | 1/2-Finale: Thun Tigers vs Zurich Renegades | 0 – 28 | U16 | – |
| 2021-10-16 18:00:1716.10.2021 | 1/2-Finale: Thun Tigers vs Luzern Lions | 55 – 7 | NLB | – |
| 2021-10-17 11:00:4317.10.2021 | 1/2-Finale: Calanda Broncos vs Bern Grizzlies | 64 – 6 | U16 | – |
| 2021-10-17 14:00:1117.10.2021 | 1/2-Finale: St. Gallen Bears vs Bienna Jets | 14 – 27 | NLB | – |
| 2021-10-17 14:00:1117.10.2021 | 1/2-Finale: LUCAF Owls vs Langenthal Invaders | 24 – 8 | NLC | – |
| 2021-10-17 14:00:2417.10.2021 | 1/2-Finale: Schaffhausen Sharks vs Morges Bandits | 32 – 12 | NLC | – |
| 2021-10-17 15:30:0017.10.2021 | Jacksonville Jaguars vs Miami Dolphins | 23 – 20 | NFL | 6 |
| 2021-10-17 19:00:0017.10.2021 | Baltimore Ravens vs Los Angeles Chargers | 34 – 6 | NFL | 6 |
| 2021-10-17 19:00:0017.10.2021 | Carolina Panthers vs Minnesota Vikings | 28 – 34 | NFL | 6 |
| 2021-10-17 19:00:0017.10.2021 | Chicago Bears vs Green Bay Packers | 14 – 24 | NFL | 6 |
| 2021-10-17 19:00:0017.10.2021 | Detroit Lions vs Cincinnati Bengals | 11 – 34 | NFL | 6 |
| 2021-10-17 19:00:0017.10.2021 | Indianapolis Colts vs Houston Texans | 31 – 3 | NFL | 6 |
| 2021-10-17 19:00:0017.10.2021 | New York Giants vs Los Angeles Rams | 11 – 38 | NFL | 6 |
| 2021-10-17 19:00:0017.10.2021 | Washington Football Team vs Kansas City Chiefs | 13 – 31 | NFL | 6 |
| 2021-10-17 22:05:0017.10.2021 | Cleveland Browns vs Arizona Cardinals | 14 – 37 | NFL | 6 |
| 2021-10-17 22:25:0017.10.2021 | Denver Broncos vs Las Vegas Raiders | 24 – 34 | NFL | 6 |
| 2021-10-17 22:25:0017.10.2021 | New England Patriots vs Dallas Cowboys | 29 – 35 | NFL | 6 |
| 2021-10-18 02:15:0018.10.2021 | Tennessee Titans vs Buffalo Bills | 34 – 31 | NFL | 6 |
| 2021-10-18 02:20:0018.10.2021 | Pittsburgh Steelers vs Seattle Seahawks | 23 – 20 | NFL | 6 |
| 2021-10-22 02:20:0022.10.2021 | Cleveland Browns vs Denver Broncos | 17 – 14 | NFL | 7 |
| 2021-10-23 15:00:3423.10.2021 | U19 Challenge: Argovia Pirates vs Luzern Lions | 0 – 12 | U19 Challenge League | – |
| 2021-10-23 17:00:5323.10.2021 | NLB Finale: Thun Tigers vs Bienna Jets | 17:00:5317:00 | NLB | – |
| 2021-10-24 02:20:0024.10.2021 | San Francisco 49ers vs Indianapolis Colts | 18 – 30 | NFL | 7 |
| 2021-10-24 11:00:0124.10.2021 | U16 Youth Bowl: Calanda Broncos vs Zurich Renegades | 12 – 8 | U16 | – |
| 2021-10-24 14:00:0624.10.2021 | NLC Finale: Schaffhausen Sharks vs LUCAF Owls | 13 – 25 | NLC | – |
| 2021-10-24 19:00:0024.10.2021 | Baltimore Ravens vs Cincinnati Bengals | 17 – 41 | NFL | 7 |
| 2021-10-24 19:00:0024.10.2021 | Green Bay Packers vs Washington Football Team | 24 – 10 | NFL | 7 |
| 2021-10-24 19:00:0024.10.2021 | Miami Dolphins vs Atlanta Falcons | 28 – 30 | NFL | 7 |
| 2021-10-24 19:00:0024.10.2021 | New England Patriots vs New York Jets | 54 – 13 | NFL | 7 |
| 2021-10-24 19:00:0024.10.2021 | New York Giants vs Carolina Panthers | 25 – 3 | NFL | 7 |
| 2021-10-24 19:00:0024.10.2021 | Tennessee Titans vs Kansas City Chiefs | 27 – 3 | NFL | 7 |
| 2021-10-24 22:05:0024.10.2021 | Los Angeles Rams vs Detroit Lions | 28 – 19 | NFL | 7 |
| 2021-10-24 22:05:0024.10.2021 | Las Vegas Raiders vs Philadelphia Eagles | 33 – 22 | NFL | 7 |
| 2021-10-24 22:25:0024.10.2021 | Arizona Cardinals vs Houston Texans | 31 – 5 | NFL | 7 |
| 2021-10-24 22:25:0024.10.2021 | Tampa Bay Buccaneers vs Chicago Bears | 38 – 3 | NFL | 7 |
| 2021-10-25 02:15:0025.10.2021 | Seattle Seahawks vs New Orleans Saints | 10 – 13 | NFL | 7 |
| 2021-10-28 02:20:0028.10.2021 | Arizona Cardinals vs Green Bay Packers | 21 – 24 | NFL | 8 |
| 2021-10-30 18:00:0830.10.2021 | Schweiz vs Russland | 9 – 36 | European Championship | – |
| 2021-10-31 02:20:0031.10.2021 | Minnesota Vikings vs Dallas Cowboys | 16 – 20 | NFL | 8 |
| 2021-10-31 19:00:0031.10.2021 | Atlanta Falcons vs Carolina Panthers | 13 – 19 | NFL | 8 |
| 2021-10-31 19:00:0031.10.2021 | Buffalo Bills vs Miami Dolphins | 26 – 11 | NFL | 8 |
| 2021-10-31 19:00:0031.10.2021 | Chicago Bears vs San Francisco 49ers | 22 – 33 | NFL | 8 |
| 2021-10-31 19:00:0031.10.2021 | Cleveland Browns vs Pittsburgh Steelers | 10 – 15 | NFL | 8 |
| 2021-10-31 19:00:0031.10.2021 | Detroit Lions vs Philadelphia Eagles | 6 – 44 | NFL | 8 |
| 2021-10-31 19:00:0031.10.2021 | Houston Texans vs Los Angeles Rams | 22 – 38 | NFL | 8 |
| 2021-10-31 19:00:0031.10.2021 | Indianapolis Colts vs Tennessee Titans | 31 – 34 | NFL | 8 |
| 2021-10-31 19:00:0031.10.2021 | New York Jets vs Cincinnati Bengals | 34 – 31 | NFL | 8 |
| 2021-10-31 22:05:0031.10.2021 | Los Angeles Chargers vs New England Patriots | 24 – 27 | NFL | 8 |
| 2021-10-31 22:05:0031.10.2021 | Seattle Seahawks vs Jacksonville Jaguars | 31 – 7 | NFL | 8 |
| 2021-10-31 22:25:0031.10.2021 | Denver Broncos vs Washington Football Team | 17 – 10 | NFL | 8 |
| 2021-10-31 22:25:0031.10.2021 | New Orleans Saints vs Tampa Bay Buccaneers | 36 – 27 | NFL | 8 |
| 2021-11-01 02:15:0001.11.2021 | Kansas City Chiefs vs New York Giants | 20 – 17 | NFL | 8 |
| 2021-11-04 02:20:0004.11.2021 | Indianapolis Colts vs New York Jets | 45 – 30 | NFL | 9 |
| 2021-11-07 02:20:0007.11.2021 | Los Angeles Rams vs Tennessee Titans | 16 – 28 | NFL | 9 |
| 2021-11-07 19:00:0007.11.2021 | Baltimore Ravens vs Minnesota Vikings | 34 – 31 | NFL | 9 |
| 2021-11-07 19:00:0007.11.2021 | Carolina Panthers vs New England Patriots | 6 – 24 | NFL | 9 |
| 2021-11-07 19:00:0007.11.2021 | Cincinnati Bengals vs Cleveland Browns | 16 – 41 | NFL | 9 |
| 2021-11-07 19:00:0007.11.2021 | Dallas Cowboys vs Denver Broncos | 16 – 30 | NFL | 9 |
| 2021-11-07 19:00:0007.11.2021 | Jacksonville Jaguars vs Buffalo Bills | 9 – 6 | NFL | 9 |
| 2021-11-07 19:00:0007.11.2021 | Miami Dolphins vs Houston Texans | 17 – 9 | NFL | 9 |
| 2021-11-07 19:00:0007.11.2021 | New Orleans Saints vs Atlanta Falcons | 25 – 27 | NFL | 9 |
| 2021-11-07 19:00:0007.11.2021 | New York Giants vs Las Vegas Raiders | 23 – 16 | NFL | 9 |
| 2021-11-07 22:05:0007.11.2021 | Philadelphia Eagles vs Los Angeles Chargers | 24 – 27 | NFL | 9 |
| 2021-11-07 22:25:0007.11.2021 | Kansas City Chiefs vs Green Bay Packers | 13 – 7 | NFL | 9 |
| 2021-11-07 22:25:0007.11.2021 | San Francisco 49ers vs Arizona Cardinals | 17 – 31 | NFL | 9 |
| 2021-11-08 02:15:0008.11.2021 | Pittsburgh Steelers vs Chicago Bears | 29 – 27 | NFL | 9 |
| 2021-11-11 02:20:0011.11.2021 | Miami Dolphins vs Baltimore Ravens | 22 – 10 | NFL | 10 |
| 2021-11-14 19:00:0014.11.2021 | Dallas Cowboys vs Atlanta Falcons | 43 – 3 | NFL | 10 |
| 2021-11-14 19:00:0014.11.2021 | Indianapolis Colts vs Jacksonville Jaguars | 23 – 17 | NFL | 10 |
| 2021-11-14 19:00:0014.11.2021 | New England Patriots vs Cleveland Browns | 45 – 7 | NFL | 10 |
| 2021-11-14 19:00:0014.11.2021 | New York Jets vs Buffalo Bills | 17 – 45 | NFL | 10 |
| 2021-11-14 19:00:0014.11.2021 | Pittsburgh Steelers vs Detroit Lions | 16 – 16 | NFL | 10 |
| 2021-11-14 19:00:0014.11.2021 | Tennessee Titans vs New Orleans Saints | 23 – 21 | NFL | 10 |
| 2021-11-14 19:00:0014.11.2021 | Washington Football Team vs Tampa Bay Buccaneers | 29 – 19 | NFL | 10 |
| 2021-11-14 22:05:0014.11.2021 | Arizona Cardinals vs Carolina Panthers | 10 – 34 | NFL | 10 |
| 2021-11-14 22:05:0014.11.2021 | Los Angeles Chargers vs Minnesota Vikings | 20 – 27 | NFL | 10 |
| 2021-11-14 22:25:0014.11.2021 | Denver Broncos vs Philadelphia Eagles | 13 – 30 | NFL | 10 |
| 2021-11-14 22:25:0014.11.2021 | Green Bay Packers vs Seattle Seahawks | 17 – 0 | NFL | 10 |
| 2021-11-15 02:15:0015.11.2021 | San Francisco 49ers vs Los Angeles Rams | 31 – 10 | NFL | 10 |
| 2021-11-15 02:20:0015.11.2021 | Las Vegas Raiders vs Kansas City Chiefs | 14 – 41 | NFL | 10 |
| 2021-11-18 02:20:0018.11.2021 | Atlanta Falcons vs New England Patriots | 0 – 25 | NFL | 11 |
| 2021-11-21 02:20:0021.11.2021 | Los Angeles Chargers vs Pittsburgh Steelers | 41 – 37 | NFL | 11 |
| 2021-11-21 19:00:0021.11.2021 | Buffalo Bills vs Indianapolis Colts | 15 – 41 | NFL | 11 |
| 2021-11-21 19:00:0021.11.2021 | Carolina Panthers vs Washington Football Team | 21 – 27 | NFL | 11 |
| 2021-11-21 19:00:0021.11.2021 | Chicago Bears vs Baltimore Ravens | 13 – 16 | NFL | 11 |
| 2021-11-21 19:00:0021.11.2021 | Cleveland Browns vs Detroit Lions | 13 – 10 | NFL | 11 |
| 2021-11-21 19:00:0021.11.2021 | Jacksonville Jaguars vs San Francisco 49ers | 10 – 30 | NFL | 11 |
| 2021-11-21 19:00:0021.11.2021 | Minnesota Vikings vs Green Bay Packers | 34 – 31 | NFL | 11 |
| 2021-11-21 19:00:0021.11.2021 | New York Jets vs Miami Dolphins | 17 – 24 | NFL | 11 |
| 2021-11-21 19:00:0021.11.2021 | Philadelphia Eagles vs New Orleans Saints | 40 – 29 | NFL | 11 |
| 2021-11-21 19:00:0021.11.2021 | Tennessee Titans vs Houston Texans | 13 – 22 | NFL | 11 |
| 2021-11-21 22:05:0021.11.2021 | Las Vegas Raiders vs Cincinnati Bengals | 13 – 32 | NFL | 11 |
| 2021-11-21 22:25:0021.11.2021 | Kansas City Chiefs vs Dallas Cowboys | 19 – 9 | NFL | 11 |
| 2021-11-21 22:25:0021.11.2021 | Seattle Seahawks vs Arizona Cardinals | 13 – 23 | NFL | 11 |
| 2021-11-22 02:15:0022.11.2021 | Tampa Bay Buccaneers vs New York Giants | 30 – 10 | NFL | 11 |
| 2021-11-25 02:20:0025.11.2021 | New Orleans Saints vs Buffalo Bills | 6 – 31 | NFL | 11 |
| 2021-11-25 18:30:0025.11.2021 | Detroit Lions vs Chicago Bears | 14 – 16 | NFL | 11 |
| 2021-11-25 22:30:0025.11.2021 | Dallas Cowboys vs Las Vegas Raiders | 33 – 36 | NFL | 11 |
| 2021-11-28 02:20:0028.11.2021 | Baltimore Ravens vs Cleveland Browns | 16 – 10 | NFL | 12 |
| 2021-11-28 19:00:0028.11.2021 | Cincinnati Bengals vs Pittsburgh Steelers | 41 – 10 | NFL | 12 |
| 2021-11-28 19:00:0028.11.2021 | Houston Texans vs New York Jets | 14 – 21 | NFL | 12 |
| 2021-11-28 19:00:0028.11.2021 | Indianapolis Colts vs Tampa Bay Buccaneers | 31 – 38 | NFL | 12 |
| 2021-11-28 19:00:0028.11.2021 | Jacksonville Jaguars vs Atlanta Falcons | 14 – 21 | NFL | 12 |
| 2021-11-28 19:00:0028.11.2021 | Miami Dolphins vs Carolina Panthers | 33 – 10 | NFL | 12 |
| 2021-11-28 19:00:0028.11.2021 | New England Patriots vs Tennessee Titans | 36 – 13 | NFL | 12 |
| 2021-11-28 19:00:0028.11.2021 | New York Giants vs Philadelphia Eagles | 13 – 7 | NFL | 12 |
| 2021-11-28 22:05:0028.11.2021 | Denver Broncos vs Los Angeles Chargers | 28 – 13 | NFL | 12 |
| 2021-11-28 22:25:0028.11.2021 | Green Bay Packers vs Los Angeles Rams | 36 – 28 | NFL | 12 |
| 2021-11-28 22:25:0028.11.2021 | San Francisco 49ers vs Minnesota Vikings | 34 – 26 | NFL | 12 |
| 2021-11-29 02:15:0029.11.2021 | Washington Football Team vs Seattle Seahawks | 17 – 15 | NFL | 12 |
| 2021-12-02 02:20:0002.12.2021 | New Orleans Saints vs Dallas Cowboys | 17 – 27 | NFL | 13 |
| 2021-12-05 02:20:0005.12.2021 | Seattle Seahawks vs San Francisco 49ers | 30 – 23 | NFL | 13 |
| 2021-12-05 19:00:0005.12.2021 | Atlanta Falcons vs Tampa Bay Buccaneers | 17 – 30 | NFL | 13 |
| 2021-12-05 19:00:0005.12.2021 | Chicago Bears vs Arizona Cardinals | 22 – 33 | NFL | 13 |
| 2021-12-05 19:00:0005.12.2021 | Cincinnati Bengals vs Los Angeles Chargers | 22 – 41 | NFL | 13 |
| 2021-12-05 19:00:0005.12.2021 | Detroit Lions vs Minnesota Vikings | 29 – 27 | NFL | 13 |
| 2021-12-05 19:00:0005.12.2021 | Houston Texans vs Indianapolis Colts | 0 – 31 | NFL | 13 |
| 2021-12-05 19:00:0005.12.2021 | Kansas City Chiefs vs Denver Broncos | 22 – 9 | NFL | 13 |
| 2021-12-05 19:00:0005.12.2021 | Miami Dolphins vs New York Giants | 20 – 9 | NFL | 13 |
| 2021-12-05 19:00:0005.12.2021 | New York Jets vs Philadelphia Eagles | 18 – 33 | NFL | 13 |
| 2021-12-05 22:05:0005.12.2021 | Las Vegas Raiders vs Washington Football Team | 15 – 17 | NFL | 13 |
| 2021-12-05 22:25:0005.12.2021 | Los Angeles Rams vs Jacksonville Jaguars | 37 – 7 | NFL | 13 |
| 2021-12-05 22:25:0005.12.2021 | Pittsburgh Steelers vs Baltimore Ravens | 20 – 19 | NFL | 13 |
| 2021-12-06 02:15:0006.12.2021 | Buffalo Bills vs New England Patriots | 10 – 14 | NFL | 13 |
| 2021-12-09 02:20:0009.12.2021 | Minnesota Vikings vs Pittsburgh Steelers | 36 – 28 | NFL | 14 |
| 2021-12-12 02:20:0012.12.2021 | Green Bay Packers vs Chicago Bears | 45 – 30 | NFL | 14 |
| 2021-12-12 19:00:0012.12.2021 | Carolina Panthers vs Atlanta Falcons | 21 – 29 | NFL | 14 |
| 2021-12-12 19:00:0012.12.2021 | Cincinnati Bengals vs San Francisco 49ers | 23 – 26 | NFL | 14 |
| 2021-12-12 19:00:0012.12.2021 | Cleveland Browns vs Baltimore Ravens | 24 – 22 | NFL | 14 |
| 2021-12-12 19:00:0012.12.2021 | Houston Texans vs Seattle Seahawks | 13 – 33 | NFL | 14 |
| 2021-12-12 19:00:0012.12.2021 | Kansas City Chiefs vs Las Vegas Raiders | 48 – 9 | NFL | 14 |
| 2021-12-12 19:00:0012.12.2021 | New York Jets vs New Orleans Saints | 9 – 30 | NFL | 14 |
| 2021-12-12 19:00:0012.12.2021 | Tennessee Titans vs Jacksonville Jaguars | 20 – 0 | NFL | 14 |
| 2021-12-12 19:00:0012.12.2021 | Washington Football Team vs Dallas Cowboys | 20 – 27 | NFL | 14 |
| 2021-12-12 22:05:0012.12.2021 | Denver Broncos vs Detroit Lions | 38 – 10 | NFL | 14 |
| 2021-12-12 22:05:0012.12.2021 | Los Angeles Chargers vs New York Giants | 37 – 21 | NFL | 14 |
| 2021-12-12 22:25:0012.12.2021 | Tampa Bay Buccaneers vs Buffalo Bills | 33 – 27 | NFL | 14 |
| 2021-12-13 02:15:0013.12.2021 | Arizona Cardinals vs Los Angeles Rams | 23 – 30 | NFL | 14 |
| 2021-12-16 02:20:0016.12.2021 | Los Angeles Chargers vs Kansas City Chiefs | 28 – 34 | NFL | 15 |
| 2021-12-19 02:20:0019.12.2021 | Tampa Bay Buccaneers vs New Orleans Saints | 0 – 9 | NFL | 15 |
| 2021-12-19 19:00:0019.12.2021 | Baltimore Ravens vs Green Bay Packers | 30 – 31 | NFL | 15 |
| 2021-12-19 19:00:0019.12.2021 | Buffalo Bills vs Carolina Panthers | 31 – 14 | NFL | 15 |
| 2021-12-19 19:00:0019.12.2021 | Cleveland Browns vs Las Vegas Raiders | 14 – 16 | NFL | 15 |
| 2021-12-19 19:00:0019.12.2021 | Detroit Lions vs Arizona Cardinals | 30 – 12 | NFL | 15 |
| 2021-12-19 19:00:0019.12.2021 | Indianapolis Colts vs New England Patriots | 27 – 17 | NFL | 15 |
| 2021-12-19 19:00:0019.12.2021 | Jacksonville Jaguars vs Houston Texans | 16 – 30 | NFL | 15 |
| 2021-12-19 19:00:0019.12.2021 | Miami Dolphins vs New York Jets | 31 – 24 | NFL | 15 |
| 2021-12-19 19:00:0019.12.2021 | New York Giants vs Dallas Cowboys | 6 – 21 | NFL | 15 |
| 2021-12-19 19:00:0019.12.2021 | Philadelphia Eagles vs Washington Football Team | 27 – 17 | NFL | 15 |
| 2021-12-19 19:00:0019.12.2021 | Pittsburgh Steelers vs Tennessee Titans | 19 – 13 | NFL | 15 |
| 2021-12-19 22:05:0019.12.2021 | Denver Broncos vs Cincinnati Bengals | 10 – 15 | NFL | 15 |
| 2021-12-19 22:05:0019.12.2021 | San Francisco 49ers vs Atlanta Falcons | 31 – 13 | NFL | 15 |
| 2021-12-19 22:25:0019.12.2021 | Los Angeles Rams vs Seattle Seahawks | 20 – 10 | NFL | 15 |
| 2021-12-20 02:15:0020.12.2021 | Chicago Bears vs Minnesota Vikings | 9 – 17 | NFL | 15 |
| 2021-12-24 02:20:0024.12.2021 | Tennessee Titans vs San Francisco 49ers | 20 – 17 | NFL | 16 |
| 2021-12-25 02:15:0025.12.2021 | Arizona Cardinals vs Indianapolis Colts | 16 – 22 | NFL | 16 |
| 2021-12-25 22:30:0025.12.2021 | Green Bay Packers vs Cleveland Browns | 24 – 22 | NFL | 16 |
| 2021-12-26 02:20:0026.12.2021 | Dallas Cowboys vs Washington Football Team | 56 – 14 | NFL | 16 |
| 2021-12-26 19:00:0026.12.2021 | Atlanta Falcons vs Detroit Lions | 20 – 16 | NFL | 16 |
| 2021-12-26 19:00:0026.12.2021 | Carolina Panthers vs Tampa Bay Buccaneers | 6 – 32 | NFL | 16 |
| 2021-12-26 19:00:0026.12.2021 | Cincinnati Bengals vs Baltimore Ravens | 41 – 21 | NFL | 16 |
| 2021-12-26 19:00:0026.12.2021 | Houston Texans vs Los Angeles Chargers | 41 – 29 | NFL | 16 |
| 2021-12-26 19:00:0026.12.2021 | Minnesota Vikings vs Los Angeles Rams | 23 – 30 | NFL | 16 |
| 2021-12-26 19:00:0026.12.2021 | New England Patriots vs Buffalo Bills | 21 – 33 | NFL | 16 |
| 2021-12-26 19:00:0026.12.2021 | New York Jets vs Jacksonville Jaguars | 26 – 21 | NFL | 16 |
| 2021-12-26 19:00:0026.12.2021 | Philadelphia Eagles vs New York Giants | 34 – 10 | NFL | 16 |
| 2021-12-26 22:05:0026.12.2021 | Seattle Seahawks vs Chicago Bears | 24 – 25 | NFL | 16 |
| 2021-12-26 22:25:0026.12.2021 | Kansas City Chiefs vs Pittsburgh Steelers | 36 – 10 | NFL | 16 |
| 2021-12-26 22:25:0026.12.2021 | Las Vegas Raiders vs Denver Broncos | 17 – 13 | NFL | 16 |
| 2021-12-27 02:15:0027.12.2021 | New Orleans Saints vs Miami Dolphins | 3 – 20 | NFL | 16 |
| 2022-01-02 02:20:0002.01.2022 | Green Bay Packers vs Minnesota Vikings | 37 – 10 | NFL | 17 |
| 2022-01-02 19:00:0002.01.2022 | Buffalo Bills vs Atlanta Falcons | 29 – 15 | NFL | 17 |
| 2022-01-02 19:00:0002.01.2022 | Chicago Bears vs New York Giants | 29 – 3 | NFL | 17 |
| 2022-01-02 19:00:0002.01.2022 | Cincinnati Bengals vs Kansas City Chiefs | 34 – 31 | NFL | 17 |
| 2022-01-02 19:00:0002.01.2022 | Dallas Cowboys vs Arizona Cardinals | 22 – 25 | NFL | 17 |
| 2022-01-02 19:00:0002.01.2022 | Indianapolis Colts vs Las Vegas Raiders | 20 – 23 | NFL | 17 |
| 2022-01-02 19:00:0002.01.2022 | New England Patriots vs Jacksonville Jaguars | 50 – 10 | NFL | 17 |
| 2022-01-02 19:00:0002.01.2022 | New Orleans Saints vs Carolina Panthers | 18 – 10 | NFL | 17 |
| 2022-01-02 19:00:0002.01.2022 | New York Jets vs Tampa Bay Buccaneers | 24 – 28 | NFL | 17 |
| 2022-01-02 19:00:0002.01.2022 | Tennessee Titans vs Miami Dolphins | 34 – 3 | NFL | 17 |
| 2022-01-02 19:00:0002.01.2022 | Washington Football Team vs Philadelphia Eagles | 16 – 20 | NFL | 17 |
| 2022-01-02 22:05:0002.01.2022 | Los Angeles Chargers vs Denver Broncos | 34 – 13 | NFL | 17 |
| 2022-01-02 22:05:0002.01.2022 | San Francisco 49ers vs Houston Texans | 23 – 7 | NFL | 17 |
| 2022-01-02 22:25:0002.01.2022 | Baltimore Ravens vs Los Angeles Rams | 19 – 20 | NFL | 17 |
| 2022-01-02 22:25:0002.01.2022 | Seattle Seahawks vs Detroit Lions | 51 – 29 | NFL | 17 |
| 2022-01-04 02:15:0004.01.2022 | Pittsburgh Steelers vs Cleveland Browns | 26 – 14 | NFL | 17 |
| 2022-01-09 19:00:0009.01.2022 | Atlanta Falcons vs New Orleans Saints | 20 – 30 | NFL | 18 |
| 2022-01-09 19:00:0009.01.2022 | Baltimore Ravens vs Pittsburgh Steelers | 13 – 16 | NFL | 18 |
| 2022-01-09 19:00:0009.01.2022 | Buffalo Bills vs New York Jets | 27 – 10 | NFL | 18 |
| 2022-01-09 19:00:0009.01.2022 | Cleveland Browns vs Cincinnati Bengals | 21 – 16 | NFL | 18 |
| 2022-01-09 19:00:0009.01.2022 | Detroit Lions vs Green Bay Packers | 37 – 30 | NFL | 18 |
| 2022-01-09 19:00:0009.01.2022 | Houston Texans vs Tennessee Titans | 25 – 28 | NFL | 18 |
| 2022-01-09 19:00:0009.01.2022 | Jacksonville Jaguars vs Indianapolis Colts | 26 – 11 | NFL | 18 |
| 2022-01-09 19:00:0009.01.2022 | Miami Dolphins vs New England Patriots | 33 – 24 | NFL | 18 |
| 2022-01-09 19:00:0009.01.2022 | Minnesota Vikings vs Chicago Bears | 31 – 17 | NFL | 18 |
| 2022-01-09 19:00:0009.01.2022 | New York Giants vs Washington Football Team | 7 – 22 | NFL | 18 |
| 2022-01-09 19:00:0009.01.2022 | Philadelphia Eagles vs Dallas Cowboys | 26 – 51 | NFL | 18 |
| 2022-01-09 19:00:0009.01.2022 | Tampa Bay Buccaneers vs Carolina Panthers | 41 – 17 | NFL | 18 |
| 2022-01-09 22:25:0009.01.2022 | Arizona Cardinals vs Seattle Seahawks | 30 – 38 | NFL | 18 |
| 2022-01-09 22:25:0009.01.2022 | Denver Broncos vs Kansas City Chiefs | 24 – 28 | NFL | 18 |
| 2022-01-09 22:25:0009.01.2022 | Los Angeles Rams vs San Francisco 49ers | 24 – 27 | NFL | 18 |
| 2022-01-09 22:25:0009.01.2022 | Las Vegas Raiders vs Los Angeles Chargers | 35 – 32 | NFL | 18 |
| 2022-01-15 10:30:0015.01.2022 | Cincinnati Bengals vs Las Vegas Raiders | 26 – 19 | NFL | 19 |
| 2022-01-16 02:15:0016.01.2022 | Buffalo Bills vs New England Patriots | 47 – 17 | NFL | 19 |
| 2022-01-16 19:00:0016.01.2022 | Tampa Bay Buccaneers vs Philadelphia Eagles | 31 – 15 | NFL | 19 |
| 2022-01-16 22:30:0016.01.2022 | Dallas Cowboys vs San Francisco 49ers | 17 – 23 | NFL | 19 |
| 2022-01-17 02:15:0017.01.2022 | Kansas City Chiefs vs Pittsburgh Steelers | 42 – 21 | NFL | 19 |
| 2022-01-18 02:15:0018.01.2022 | Los Angeles Rams vs Arizona Cardinals | 34 – 11 | NFL | 19 |
| 2022-01-22 22:30:0022.01.2022 | Tennessee Titans vs Cincinnati Bengals | 16 – 19 | NFL | 20 |
| 2022-01-23 02:15:0023.01.2022 | Green Bay Packers vs San Francisco 49ers | 10 – 13 | NFL | 20 |
| 2022-01-23 21:00:0023.01.2022 | Tampa Bay Buccaneers vs Los Angeles Rams | 27 – 30 | NFL | 20 |
| 2022-01-24 00:30:0024.01.2022 | Kansas City Chiefs vs Buffalo Bills | 00:30:000:30 | NFL | 20 |
| 2022-01-30 21:00:5930.01.2022 | Kansas City Chiefs vs Cincinnati Bengals | 21:00:5921:00 | NFL | – |
| 2022-01-31 00:30:4431.01.2022 | Los Angeles Rams vs San Francisco 49ers | 00:30:440:30 | NFL | – |
